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Integrating Synthetic Biology with Hepatogenous Diabetes Treatments

Caleb Sooknanan ‘20 Hepatogenous diabetes is a condition often characterized by the comorbid presence of type 2 diabetes with chronic liver disease. A major factor in this condition is insulin resistance (IR), an asymptomatic disease state in which impaired insulin signaling causes organ dysfunction. Current therapies that target IR are limited and generally inapplicable for…

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A Mechanical Thorax for CPR Simulation

Caleb Sooknanan ’20 For the past few decades, cardiopulmonary resuscitation (CPR) guidelines have been regulated on the basis of chest compression, medication procedures, and other criteria. However, the circulation generated via CPR varies with intensity and duration of compressions, which can be inconsistent. As studies evaluating such inconsistencies have been relegated to animal or computer…

The Importance of Synthetic Core Promoters in Yeast Fine-Tuning Expression

    By Caleb Sooknanan ‘20 In genetic engineering, metabolic pathways and genetic circuits can be manipulated in microbes to produce chemicals or activate certain functions. To do this, gene expression must be fine-tuned to balance and optimize protein levels of metabolic enzymes or regulators.  Manipulating these in unicellular eukaryotes often involves core promoter sequences,…

Photocurable Bioinks and 3D-Printed Hydrophilic Drugs

  By Caleb Sooknanan ’20 Pharmaceutical dosages are often defined as the amount of active pharmaceutical ingredient (API) that has a therapeutic effect in the most patients. Using such a generalized method does not account for variations in patient genomic and pathophysiological status, leading to potential negative side-effects. Personalized medicine intends to provide patients with…