Brain Cancer and SENP1Silencing

By Daniel Walocha ‘19 Astrocytomas are the most common type of glioma and contain the most detrimental subtype of brain cancers, glioblastoma multiforme. Astrocytomas affect the astrocytes in the brain, which make up the blood-brain barrier. Xia et al. from Purdue University looked to study the effect of SUMO-specific protease 1 (SENP1) knockout in cell…

Urethral Carcinoma

By Daniel Walocha ‘19 Urethral carcinomas are not understood well enough to be mapped out for clinical and pathologic description. The cellular shape and function has been described to be squamous (flattened) and aggressive due to its ability to metastasize to distant organs. The mean survival and follow-up with patients offer a correlation between urethral…

TIGAR Protein Associated Survival in Viral Carcinogenesis

By Daniel Walocha ‘19 Oncogene overexpression will lead to cancer phenotypes that can accumulate cytotoxic metabolites, reactive oxygen species (ROS), and other apoptosis-inducing factors in the cell. It is therefore necessary for the cancerous cell to eliminate the apoptosis-inducing factors or suppress apoptosis altogether. Dr. Megan Romeo et al. from Richland College has detected a…

Intelligence in the HTT Gene

By Daniel Walocha ‘19 Huntington’s Disease is caused by a trinucleotide repeat of the HTT gene. The wild type has a repeat ranging from 10 to 35, but beyond 39 repeats causes the disease characterized by significant impairments in the basal ganglia and neurodegeneration. The CAG repeats in the HTT gene cause the production of…

Long Non-Coding RNA NEAT1 Analysis

By Daniel Walocha ‘19 Long non-coding RNAs (lncRNAs) serve normal cell functions in growth, differentiation, and controlled cell death. The lncRNA’s are modulated in cancer cells to provide a pro-survival, oncogenic role in many different types of cancer. However, lncRNA’s have also been seen, when unchanged, to provide tumor suppressive activities in normal cells. Nuclear…

CD133’s Role in Esophageal Cancer Cells

By Daniel Walocha ‘19 CD133 is a biomarker for cancer stem cells (CSC) in esophageal squamous cell carcinomas (ESCC). Cancer cells have remarkable resistance to drugs and therapies, so discovering a potential therapeutic target to make the CSCs in ESCC more susceptible to treatment is of particular interest. Dr. Wen Xu et al. from Columbia…

EYA1 and its Overexpression in Colorectal Cancer Associated with Angiogenesis

By Daniel Walocha ‘19 Angiogenesis is the formation of blood vessels. Cancer cells release growth factors associated with the induction of angiogenesis. Newly formed blood vessels allow cancer cells to easily metastasize, making treatment and survivability difficult for tumors. Colorectal cells are the third leading cause of cancer deaths, so understanding potential therapeutic targets is…