Mucopolysaccharidoses Treatment with Gene Therapy

By Daniel Walocha ‘19 Muscopolysaccharidoses (MPS) is a lysosomal storage disorder which results from a deficiency of lysosomal enzymes. The lack of enzymes causes an accumulation of glycosaminoglycans that can lead to severe symptoms including heart disease, nervous system damage, and skeletal dysplasia. Enzyme replacement therapies, hematopoietic stem cell transplantation, and substrate reduction therapy are…

Nanomaterial’s Potential in Cancer Immunotherapy

By Daniel Walocha ‘19 Immunotherapy is a promising therapy that has potential since it uses the patient’s own immune system to kill cancer cells. This unique quality that is not usually present in radiation or chemotherapy has promise in that it can present a durable treatment that limits metastasis and future recurrences. Since cancer cells…

FOXO Proteins Role in Cancer Pathways

By Daniel Walocha ‘19 FOXO proteins have previously been established as transcription factors in genes controlling mitogenic cell growth, metabolism, and proliferation. They contain a common sequence, the forkhead box, which encodes for a string of 80-100 amino acids which form a DNA-binding motif. Though, the specific cancer pathways and crosstalk among the signaling proteins…