Disruption of GABPβ1L Reverses Immortality of Glioblastoma Cells

By Riya Gandhi ‘22 Researchers in the Department of Neurological Surgery at the University of California have made a progressive discovery regarding tumor cell immortality, especially in brain-related cancers such as glioblastoma, which recently claimed the life of Senator John McCain. Their work involved TERT promoter mutations, which are responsible for activating telomerase and thereby…

Somatic Mutations as Markers for Size and Lifetimes of Blood Stem Cells

By Riya Gandhi ‘22 Despite the importance of hematopoiesis — a process that balances production and destruction of specialized blood cells — in the human body, scientists were unable to quantify the population size and lifetime dynamics that govern the process until now. Researchers from the Wellcome-Trust Sanger Institute, Wellcome-MRC Cambridge Stem Cell Institute, and…