Inducing Leukemia Cell Death Through the Inhibition of Amino Acids

By Riya Gandhi ‘22 Thanks to chemotherapy, acute myeloid leukemia (AML) is not the most fatal kind of cancer. However, the same chemotherapy that treats the disease may also revitalize leukemia stem cell populations, thereby increasing the probability of relapse. As such, scientists are still actively researching alternative treatments and cures. Most recently, researchers looked…

Expression of Transcription Factor TP63 Reprograms Squamous Pancreatic Ductal Adenocarcinoma Cells

By Riya Gandhi ‘22 Although pancreatic cancer is not the most common type of cancer, the prognosis for those diagnosed with the disease is very poor. Much like any other cancer, pancreatic cancer develops when cells in the organ multiply at an uncontrollable rate. Pancreatic ductal adenocarcinoma (PDA), the most common type of pancreatic cancer,…

Inducing Tumor Cell Death by RIG-I: The Future of Breast Cancer?

By Riya Gandhi ‘22 In recent years cancer therapy – especially cancer immunotherapy – has gained momentum and scientists’ interest has turned to immune checkpoint inhibitors (ICIs). ICIs aid in the suppression of checkpoint receptors to produce powerful immune responses against tumors. Although such a procedure is gaining momentum in clinical settings, much research must…

Disruption of GABPβ1L Reverses Immortality of Glioblastoma Cells

By Riya Gandhi ‘22 Researchers in the Department of Neurological Surgery at the University of California have made a progressive discovery regarding tumor cell immortality, especially in brain-related cancers such as glioblastoma, which recently claimed the life of Senator John McCain. Their work involved TERT promoter mutations, which are responsible for activating telomerase and thereby…