Disruption of GABPβ1L Reverses Immortality of Glioblastoma Cells

By Riya Gandhi ‘22 Researchers in the Department of Neurological Surgery at the University of California have made a progressive discovery regarding tumor cell immortality, especially in brain-related cancers such as glioblastoma, which recently claimed the life of Senator John McCain. Their work involved TERT promoter mutations, which are responsible for activating telomerase and thereby enabling cell immortality. Approximately 90 percent of human tumors reactivate … Continue reading Disruption of GABPβ1L Reverses Immortality of Glioblastoma Cells

Somatic Mutations as Markers for Size and Lifetimes of Blood Stem Cells

By Riya Gandhi ‘22 Despite the importance of hematopoiesis — a process that balances production and destruction of specialized blood cells — in the human body, scientists were unable to quantify the population size and lifetime dynamics that govern the process until now. Researchers from the Wellcome-Trust Sanger Institute, Wellcome-MRC Cambridge Stem Cell Institute, and the University of Cambridge conducted a recent study under principle … Continue reading Somatic Mutations as Markers for Size and Lifetimes of Blood Stem Cells

Malignant Regenerative Cells Induced by Chemotherapy: A Possible Cause of AML Relapse

By Riya Gandhi ‘22 Relapse of acute myeloid leukemia (AML) — or any type of cancer, for that matter — has always posed an enormous challenge to patients and physicians alike. However, a recent study conducted by researchers at McMaster University has found that it is not predominantly leukemic stem cells that induce such recurrence but rather leukemic-regenerating cells that arise post-chemotherapy. In this study, … Continue reading Malignant Regenerative Cells Induced by Chemotherapy: A Possible Cause of AML Relapse