Distinct Fibroblast Subsets Drive Inflammation and Damage in Arthritis

By Nicole Zhao ‘20  Arthritis is an inflammation of one or more joints with symptoms such as joint pain and stiffness (1). One common type of arthritis is rheumatoid arthritis, an inflammatory disease in which the immune system targets the synovial membrane of the joints and causes joint damage (1). The synovial membrane normally protects and lubricates the joints. Previous studies have found that the … Continue reading Distinct Fibroblast Subsets Drive Inflammation and Damage in Arthritis

Optimizing Treatment for Diabetic Patients With Coronary Artery Disease

By Allan Mai ‘20 There are currently 415 million people worldwide living with diabetes; this number is expected to rise to 640 million by the year 2040. Complications, especially coronary artery disease (CAD), is one of the leading causes of death in diabetic patients; conversely, optimizing management of such complications can also significantly increase lifespan. While the previous assumption was that good glycemic control would … Continue reading Optimizing Treatment for Diabetic Patients With Coronary Artery Disease

South Asians Have the Highest Rates of Heart Disease

By Nicole Zhao ’20 Heart disease is the leading cause of death for both men and women worldwide. However, people of South Asian descent have a higher death rate from heart disease than any other group. Following a variety of diets, from omnivorous to vegetarian, South Asians are four times more likely to be diagnosed with heart disease even at normal body weight and tend … Continue reading South Asians Have the Highest Rates of Heart Disease

Sleep Modulates Hematopoiesis and Protects Against Atherosclerosis

By Nicole Zhao ’20 Numerous pathological conditions such as obesity, diabetes, cancer, and cardiovascular disease have been connected to insufficient or interrupted sleep. However, little is known about the specific mechanisms by which sleep maintains health. In this study, it was found that sleep regulates hematopoiesis and protects against atherosclerosis in mice. Hematopoiesis is the process of forming blood cellular components from stem cells. Research … Continue reading Sleep Modulates Hematopoiesis and Protects Against Atherosclerosis

The effect of diabetes on fingernail quality

By Kavindra Sahabir ‘21 In our current public understanding, Type 2 diabetes (T2D) is associated with the need for sugar-free foods and blood sugar monitors. Beyond a high blood sugar level however, it also causes chronic degradation and damage to nerves, joints, and other bodily tissues. A study done by Dr. Silhota and team endeavored to determine whether the fingernail could be a useful site … Continue reading The effect of diabetes on fingernail quality

Inducing Leukemia Cell Death Through the Inhibition of Amino Acids

By Riya Gandhi ‘22 Thanks to chemotherapy, acute myeloid leukemia (AML) is not the most fatal kind of cancer. However, the same chemotherapy that treats the disease may also revitalize leukemia stem cell populations, thereby increasing the probability of relapse. As such, scientists are still actively researching alternative treatments and cures. Most recently, researchers looked into the importance of amino acids for preventing the growth … Continue reading Inducing Leukemia Cell Death Through the Inhibition of Amino Acids

Expression of Transcription Factor TP63 Reprograms Squamous Pancreatic Ductal Adenocarcinoma Cells

By Riya Gandhi ‘22 Although pancreatic cancer is not the most common type of cancer, the prognosis for those diagnosed with the disease is very poor. Much like any other cancer, pancreatic cancer develops when cells in the organ multiply at an uncontrollable rate. Pancreatic ductal adenocarcinoma (PDA), the most common type of pancreatic cancer, garnered the attention of researchers at Cold Spring Harbor Laboratory … Continue reading Expression of Transcription Factor TP63 Reprograms Squamous Pancreatic Ductal Adenocarcinoma Cells

Infectious Diseases may Cause Major Depressive Disorder

By: Marianna Catege Depression may actually be infectious, according to Dr. Turhan Canli, the Associate Professor of Psychology and Radiology at Stony Brook University. His claim puts Major Depressive Disorder (MDD) in a new light, one that suggests it can be caused by parasitc bacterial or viral infections. In this highly prevalent disease, with roughly 7 percent of the U.S. population developing MDD, symptoms can … Continue reading Infectious Diseases may Cause Major Depressive Disorder

Aristolochic Acid and Chemically Modified Curcumin: an Overview

By Michael Baxter Dr. Francis Johnson received his Ph. D. from Glasgow University in Scotland in 1954 and went on to become a postdoctoral fellow at Boston University until 1957. He worked at the Dow Eastern Research Laboratory before coming to Stony Brook University in 1973, where he became the founding vice-chairman of the Department of Pharmacological Sciences [1]. Currently Dr. Johnson is part of … Continue reading Aristolochic Acid and Chemically Modified Curcumin: an Overview

Aristolochic Acid, used in herbal remedies, linked to urothelial cancers and neuropathic diseases

By Katherine Maiorisi Dr. Grollman of Stony Brook University was honored in 2011 with the Environmental Mutagen Society (EMS) award for his work on aristolochic acid (AA) and its relation to cancer and neuropathy [1]. Throughout the past fifty years studies have been done on the effect of environmental agents on neuropathy. Aristolochia poisoning was first proposed in 1969 by Ivi´c, but was disregarded, until … Continue reading Aristolochic Acid, used in herbal remedies, linked to urothelial cancers and neuropathic diseases