Figure 1: This is an illustration depicting the difference between healthy muscle cells (shown on the right) and muscle cells affected by muscle dystrophy (shown on the left). Due to the degeneration of the muscle cells, they will appear much smaller than usual.

Correcting Muscular Dystrophy Gene Mutations

Richard Liang 18’ Duchenne muscular dystrophy (DMD) is a severe form of muscle degeneration that can become lethal if it affects heart muscle. It is known to be caused by mutations in the X-linked dystrophin-coding gene and thus, there has been ongoing research in correcting these mutations. Currently, there is no effective treatment for this…

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A Mechanical Thorax for CPR Simulation

Caleb Sooknanan ’20 For the past few decades, cardiopulmonary resuscitation (CPR) guidelines have been regulated on the basis of chest compression, medication procedures, and other criteria. However, the circulation generated via CPR varies with intensity and duration of compressions, which can be inconsistent. As studies evaluating such inconsistencies have been relegated to animal or computer…

New and Revolutionary Treatment for Bacterial Infection

By Patrick Yang ’20 Bronchiectasis occurs when the lung’s bronchial tubes are permanently damaged or inflamed, leading to chest pain, coughing up blood, and large production of mucus. These damaged lung walls also make bronchiectasis patients more prone to chronic infection and, specifically, Pseudomonas aeruginosa lung infections, which increase mortality rates. However, previous research has…

Figure 1. Artificially sweetened drinks are connected to a greater risk for stroke and dementia.

Sugary Drinks vs. Healthy Brains

By Taylor Ha ’18 Many American consumers regularly indulge in hundreds of sugar- and artificially- sweetened name brand drinks: Coke, Sprite, Fanta soda, and Hawaiian punch, to name a few. However, routine consumption of such drinks is associated with cardiometabolic diseases, which can amplify stroke and dementia risk. And according to new research published on…

Figure 1. High dosages of vitamin C are selectively toxic to cancer cells and can enhance cancer therapies.

Vitamin C Enhances Cancer Therapy

By Patrick Yang ’20 Ascorbate, or vitamin C, is a potential anti-cancer agent when paired with chemotherapy. Scientists hypothesize that ascorbate’s curative powers stem from its ability to produce hydrogen peroxide, which reduces iron to form free radicals – highly reactive molecules that damage DNA and cause cell death. Since aggressive cancers have unusually large…

Caption: A mathematical model predicts sleep patterns impacted by artificial light and socially established schedules.

Model Predicts Sleep Patterns

Meghan Bialt-DeCelie – ’19 Rapid modernization has had an impact on the hours that humans are active, disrupting natural and established rhythms. A team led by Anne Skeldon, PhD, developed a mathematical model that shows the effect of factors like artificial light on the human circadian rhythm and sleeping habits. The mathematical model included three…