Cysteine-Rich γ-Crystallins Evolutionary Role in Lens Transparency and Function

Eimaan Bilal, Class of 2028 Cysteine (Cys) is a sulfur-containing amino acid found in crystallin proteins that compose our eye’s lens. When Cys is oxidized, it can lead to crystallin protein misfolding and unwanted disulfide bonding, causing light-scattering aggregation. Light-scattering aggregation in crystallin proteins is one of the main contributors to cataract disease, which clouds the lens and can even develop into blindness. Since Cys … Continue reading Cysteine-Rich γ-Crystallins Evolutionary Role in Lens Transparency and Function