Tag: CRISPRCas9

2024-25, Cellular and Molecular Science, Chemistry, Molecular Biology

FOXO1: A Memory Upgrader for T-cells!

Author: Farzad Hoque, Class of 2028 The persistence and effectiveness of chimeric antigen receptor (CAR) T-cell therapies depend significantly on the ability of these cells to maintain memory-like states while avoiding exhaustion. Recent research has identified the transcription factor FOXO1 as a critical regulator of memory programming in CAR T cells, offering transformative insights into improving therapeutic outcomes. Alexander E. Doan and colleagues conducted a … Continue reading FOXO1: A Memory Upgrader for T-cells!

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Environment, Evolution, Natural World

CRISPR Editing in Fruit Flies to Mimic Monarch Butterflies

Ellie Teng ‘21 Monarch butterflies can consume toxic milkweed plants due to mutations in their genome. Both the caterpillar and the butterfly store the consumed toxins to defend against predators. Eating a monarch would cause a predator to regurgitate. Researchers at the University of California, Berkeley have utilized the CRISPR-Cas9 tool to genetically modified harmless fruit flies (Drosophila melanogaster) to have the ability to eat … Continue reading CRISPR Editing in Fruit Flies to Mimic Monarch Butterflies

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