The Use of CRISPR/Cas9 Gene Editing Tool in Treating Early Onset Alzheimer’s Disease

Stephanie Budhan ‘20 Early-onset Alzheimer’s disease (AD) is dominantly inherited genetic disorder that causes the development of Alzheimer’s Disease in individuals younger than 65 years old. AD is caused by a point mutation in three major genes, one of which is amyloid precursor protein (APP). APP is cleaved to generate beta amyloid which makes up the amyloid plaque found in the brains of AD patients. … Continue reading The Use of CRISPR/Cas9 Gene Editing Tool in Treating Early Onset Alzheimer’s Disease

Figure 1. Brood of chickens frolicking in a pen house

Fighting the Avian Leukosis Virus through Genome Modification

By Matthew Lee ’21 The avian leukosis virus subgroup J (ALV-J) has plagued the poultry industry since being recognized about 30 years ago. The economic hardships caused by decreases in poultry yield makes developing resistance mechanisms a topic of interest. Recently, a team led by Hong Jo Lee from Seoul National University decided to take the novel approach of editing the chicken genome in order … Continue reading Fighting the Avian Leukosis Virus through Genome Modification