Anti-NMDAR Autoantibodies Disrupt Ionotropic Receptor Signaling

Vignesh Subramanian ’24 N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels whose signaling enables higher-order functions, such as learning and memory, throughout the brain. They are activated by glutamate, the major excitatory neurotransmitter in the central nervous system, and are dynamically distributed across synaptic and extrasynaptic sites. The obligate composition of these protein receptors includes two subunits known as GluN1 paired with combinations of spliced regulatory … Continue reading Anti-NMDAR Autoantibodies Disrupt Ionotropic Receptor Signaling