Tag: plaque

Cellular and Molecular Science, Molecular Biology, Neuroscience

Diminished Glymphatic Transport and Lymphatic Drainage Tied to Cerebral Amyloid Angiopathy

Author: Vignesh Subramanian, Class of 2024 Cerebral amyloid angiopathy (CAA) is a cerebrovascular disorder characterized by the accumulation of amyloid protein deposits along cortical capillaries, cerebral vessel walls, and the brain’s leptomeninges. These plaques weaken fragile blood vessels, often resulting in intracerebral hemorrhaging. CAA is linked to vascular cognitive impairment and dysfunction and is a major contributor to the pathogenesis of Alzheimer’s disease (AD) and … Continue reading Diminished Glymphatic Transport and Lymphatic Drainage Tied to Cerebral Amyloid Angiopathy

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Neuroscience

Microglial Activation Promotes AD-Affiliated Plaque Formation

Vignesh Subramanian ’24 Alzheimer’s disease (AD) is a neurodegenerative disorder and form of dementia that causes progressive loss of memory, critical thinking skills, and behavioral capabilities. The disease is characterized by the extracellular aggregation of beta (β)-amyloid plaques. These buildups gradually interfere with proteostasis, the regulation of protein synthesis and degradation, and decrease levels of neurotransmitter signaling between neurons. However, the failure of microglia – … Continue reading Microglial Activation Promotes AD-Affiliated Plaque Formation

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