Tag: T-cell

2024-25, Cellular and Molecular Science, Chemistry, Molecular Biology

FOXO1: A Memory Upgrader for T-cells!

Author: Farzad Hoque, Class of 2028 The persistence and effectiveness of chimeric antigen receptor (CAR) T-cell therapies depend significantly on the ability of these cells to maintain memory-like states while avoiding exhaustion. Recent research has identified the transcription factor FOXO1 as a critical regulator of memory programming in CAR T cells, offering transformative insights into improving therapeutic outcomes. Alexander E. Doan and colleagues conducted a … Continue reading FOXO1: A Memory Upgrader for T-cells!

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Cancer, Cell Cycle

BH4’s Role in T- Cell Proliferation in Autoimmunity and Cancer

By Allan Mai ‘20 BH4 is an important regulator of many bodily functions. Among its most important functions are its involvement in the production of monoamine neurotransmitters, its generation of nitric oxide, and its role in pain. However, Shane Cronin and his team recently uncovered another important function of this cofactor: proliferation of T cells, which are an integral part of the immune response. Inhibitions … Continue reading BH4’s Role in T- Cell Proliferation in Autoimmunity and Cancer

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