Potential for Enhanced Cancer Therapy by Allosteric Inhibition of Phosphoglycerate Mutase

Jorge Pincay ’20 Phosphoglycerate mutase 1 (PGAM1) is a gene known to promote rapid tumor growth and invasiveness in several cancers, including non-small cell lung cancer (NSCLC). PGAM1 encodes for an enzyme that catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate in the glycolytic pathway,  a compound that coordinates anabolic biosynthesis. In many forms of cancer, including NSCLC, urothelial bladder cancer, and hepatocellular carcinoma, upregulation of … Continue reading Potential for Enhanced Cancer Therapy by Allosteric Inhibition of Phosphoglycerate Mutase

Common Fungi May Drive Pancreatic Cancer

Nicole Zhao ’20 Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide and occurs more frequently in developed countries (1). What makes pancreatic cancer even more alarming is that patients seldom exhibit symptoms until an advanced stage of the disease when little can be done for them (1). Therefore, techniques in early detection and risk assessment are crucial in the prognosis of a … Continue reading Common Fungi May Drive Pancreatic Cancer

The Association Between Coffee Products and Breast Cancer Risk in Hong Kong

Ayesha Azeem ‘23 In women, breast cancer is universally seen as the most common cancer, with diet being one of the most important factors in causing the condition. Coffee is one of the most popular drinks available in the world and, in Hong Kong, a recent fan-favorite. From 2010 to 2018, coffee revenue skyrocketed from 119 million USD to 279 million USD. With the obvious … Continue reading The Association Between Coffee Products and Breast Cancer Risk in Hong Kong

Sugary Drinks Increase Risk of Cancer

Ellie Teng ‘21 Added sugars were long known to have adverse health benefits, but sugary drinks were recently found to be linked to cancer. An increase in the consumption of sugary drinks the past decade is associated with the increase in obesity, which is a risk factor for various cancers. In France, a group of researchers assessed the connection between  the consumption of sugary drinks … Continue reading Sugary Drinks Increase Risk of Cancer

Cancer Cell Debris Generated by the Longstanding Chemotherapeutic 5-Fluorouracil is Linked to Oncogenic Inflammation

Shrey Thaker ‘22 The centerpiece of clinical struggle against cancer is the recurrence of the tumor following extensive chemotherapy. The most common chemotherapeutic agent dispatched to patients suffering from colon cancer is known as 5-Fluorouracil (5-FU) and its main mechanism of action includes inducing apoptosis by inflicting DNA damage and triggering the cell’s natural apoptotic pathways. While the initial effect of tumor cell death is … Continue reading Cancer Cell Debris Generated by the Longstanding Chemotherapeutic 5-Fluorouracil is Linked to Oncogenic Inflammation

Costunolide: A Potential Drug Molecule for Fighting Gastric Cancer

Nomrota Majumder ‘21 Costunolide, a sesquiterpene lactone extracted from Radix Aucklandiae, is shown to have powerful activity against multiple cancer forms. However, the effects of costunolide has not yet been investigated with gastric cancer, or the formation and growth of malignant cancer cells lining the stomach. As the fifth most common cancer in the world, and the third leading cause of cancer related death in … Continue reading Costunolide: A Potential Drug Molecule for Fighting Gastric Cancer

Utilizing Heat Shock Protein 90 in Breast Cancer Imaging: A Cheaper Alternative?

By Riya Gandhi ‘22 In the current day and age, therapeutic procedures for breast cancer–such as chemotherapy, radiation therapy, and surgery–are at the forefront of the initiative to manage cancer effectively. Across the globe, there are nations where the resources for such treatments are readily available. However, what about the low to middle income nations? Unfortunately, many of these countries, which hold higher rates of … Continue reading Utilizing Heat Shock Protein 90 in Breast Cancer Imaging: A Cheaper Alternative?

Assessing the Risk: The Susceptibility of a Cancer Patient to Acute Kidney Injury

By Riya Gandhi ‘22 Due to their ability to purify blood and remove wastes, the kidneys are regarded as the filtration system for the human body. As such, they are one of the most crucial organs. However, what happens one or both of your kidneys are damaged, or worse, fail completely? Such an occurrence is known as acute kidney injury (AKI) and can transpire within … Continue reading Assessing the Risk: The Susceptibility of a Cancer Patient to Acute Kidney Injury

Invasion of the Gboxins: Inhibiting the Proliferation of Glioblastoma Cells

By Riya Gandhi ‘22 The aggressive proliferation of glioblastoma cells is characteristic of glioblastoma multiforme (GBM), a fatal cancer of the brain. As much as treatments may help, patients with this cancer typically relapse. Furthermore, radiotherapy and chemotherapy unintentionally target and poison normal proliferating cells, thereby harming the wellbeing of the patients. However, under principle investigator Dr. Yufeng Shi, researchers at the Cancer Biology & … Continue reading Invasion of the Gboxins: Inhibiting the Proliferation of Glioblastoma Cells

Neutrophils Escort Circulating Tumor Cells and Increase Metastatic Potential

By Nicole Zhao ’20 Numerous cancer research projects are dedicated to investigating the primary tumor and its microenvironment. Though this is undoubtedly important, the role of immune cells during cancer dispersion in the blood cells is largely uncharacterized. Circulating tumor cells (CTCs) lead to metastasis of several types of cancers and its levels are often a predictor of survival rate. These cells are often found … Continue reading Neutrophils Escort Circulating Tumor Cells and Increase Metastatic Potential