Category: Medicine and Physiology

2022-23, Biology, Medicine and Physiology, Neurology

Development of Innovative Burn Assessment Technique Using Neural Network

Julia Chivu ’23 The current burn injury evaluation methods available for clinical use are ineffective and outdated. These circumstances are problematic as the initial injury assessment is necessary to ensure the best clinical treatment plan for the patient. Burns can lead to deep tissue damages, necrosis, and severe scarring. Without a proper course of action, the injury can negatively impact the patient’s quality of life, … Continue reading Development of Innovative Burn Assessment Technique Using Neural Network

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2022-23, Biology, Cancer, Medicine and Physiology

Predicting the Future: The Prognostic Value of Tumor Budding and Microenvironment in Colon Cancer

Peter Gillespie ’25 Can the success of cancer treatment be predicted before treatment begins? Findings from Dr. Wen and his colleagues at Stony Brook Medicine suggest that certain characteristics of the tumor and the microenvironment can predict the success of treatment in colon cancer patients. Dr. Wen and colleagues investigated the prognostic ability of intratumoral budding, which is the presence of one or a few … Continue reading Predicting the Future: The Prognostic Value of Tumor Budding and Microenvironment in Colon Cancer

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2022-23, Health and Medicine, Medicine and Physiology, mental health, Sociology, Year

Black Patients More Likely Than White Patients to Suffer Negative Outcomes After Spine Surgery

By: Jessica George, Class of 2024 Figure 1: Disparities in healthcare outcomes may be due to systemic biases in healthcare delivery Racial disparities in healthcare outcomes have been well-documented in numerous studies, including those focused on surgical procedures. Despite advances in surgical techniques and technologies, disparities in surgical outcomes persist, with some racial and ethnic groups experiencing worse outcomes than others. Understanding the factors that … Continue reading Black Patients More Likely Than White Patients to Suffer Negative Outcomes After Spine Surgery

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2022-23, Health and Medicine, Medicine and Physiology, Pharmacology

Potential for Macrophage Cell Cultures to Produce New Medications

Julia Chivu ’23 Macrophages typically dominate the immune system with broad responsibilities related to cell repair, immune response, and homeostasis. However, macrophages also have organ-specific functions embedded into their epigenetic makeup. These powerful and specialized cells may be used in various macrophage therapies that can impact both humans and animals. In spite of this astounding potential, these treatment options are not available yet since scientists … Continue reading Potential for Macrophage Cell Cultures to Produce New Medications

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2022-23, Cancer, Health and Medicine, Medicine and Physiology

Increased Movement of Cancer Cells in Fluids of High Viscosity Hints at Possible Control Mechanism

Sooraj Shah ’24 With more than 1.9 million individuals in the US being diagnosed with cancer each year, research revolving around the behavior of cancer cells is an important aspect of the search for better treatments. The study of cancer cells in biological assays within a lab has led to great research regarding the structure, motion, and activity of cancer cells in-vitro. A specific part … Continue reading Increased Movement of Cancer Cells in Fluids of High Viscosity Hints at Possible Control Mechanism

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2022-23, Disease, Health and Medicine, Medicine and Physiology

Past Pandemics May Play a Role in Susceptibility to Disease

Melanie Karniewich ’25 When the human body reacts to something foreign, the immune response will likely ensure that the human body is unharmed. For example, when receiving a vaccine, the body remembers the virus being injected and will know how to fight it off the next time. A recent study identified traces of immune genes associated with the Black Death from the 1300s in current … Continue reading Past Pandemics May Play a Role in Susceptibility to Disease

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Medicine and Physiology

Overexpression of FABP3 contributive to Aging Skeletal Muscle via ER stress

Sooraj Shah ’24 Sarcopenia is a disease which leads to the loss of muscle mass and function by skeletal muscle. According to Dr. Stephan von Haehling (2), a professor at Charité Medical School, the disease affects nearly 5-13% of adults 60-70 years of age, and rises to 11-50% of adults 80 years of age and older. While Sarcopenia is known to be caused by factors … Continue reading Overexpression of FABP3 contributive to Aging Skeletal Muscle via ER stress

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Medicine and Physiology, Pharmacology

The Role of Gene Expression Variation in the Development of Mammalian Drug Resistance

Simran Kaur ‘20 Designing drugs is often challenging because identical cells within a specific network will exhibit varying genetic expression (noise), resulting in drug resistance. The source of this variation is most often stochastic, accumulations of random fluctuations occurring during transcription, translation, and post-translational regulation. Gene expression noise currently poses as the greatest barrier in finding a cure for cancer and Human Immunodeficiency Virus (HIV). … Continue reading The Role of Gene Expression Variation in the Development of Mammalian Drug Resistance

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Disease, Health, Medicine and Physiology, Pharmacology

Chloroquine as a Promising Anti-Viral Drug in Immunocompromised Patients Amidst the COVID-19 Pandemic

Simran Kaur ‘20 SARS-CoV-2, a new type of coronavirus, is responsible for a global pandemic that currently has infected hundreds of thousands of individuals worldwide. The virus belongs to the same family of viruses responsible for certain cases of the common cold, Middle East Respiratory Syndrome, and Sudden Acute Respiratory Syndrome (SARS). The virus is incredibly contagious, spreading through respiratory droplets and exploiting commonly-found human … Continue reading Chloroquine as a Promising Anti-Viral Drug in Immunocompromised Patients Amidst the COVID-19 Pandemic

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Cancer, Cellular and Molecular Science, Health and Medicine, Medicine and Physiology

Different Types of Anesthesia can Impact Breast Cancer Metastasis.

Priyanshi Patel ‘22 Metastasis refers to the surgical removal of solid tumors and metastasis is the main cause of cancer death. Previously, not much was known about the role anesthetics play in cancer metastasis. Complete surgical removal of solid tumors offers the possibility of a cure and is the basic treatment provided. Despite surgery, recurrent metastasis in vital organs does reoccur and is a major … Continue reading Different Types of Anesthesia can Impact Breast Cancer Metastasis.

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Cellular and Molecular Science, Medicine and Physiology, Molecular Biology

CRISPR-Edited Stem Cells as a Potential Therapeutic Target for Cancer in Immunocompromised Individuals

Simran Kaur ‘20 CRISPR-Cas9 technology has been used to edit the mammalian genome for decades, allowing scientists to remove, add, and change sections of DNA sequences. The human immunodeficiency virus (HIV) does not have a cure that exists, but studies have shown that allogeneic transplantation of STEM cells into diagnosed patients can eradicate the virus. CCR5 is the coreceptor for the entry of HIV into … Continue reading CRISPR-Edited Stem Cells as a Potential Therapeutic Target for Cancer in Immunocompromised Individuals

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Health, Health and Medicine, Medicine and Physiology

Study Reveals Ability of Human Cartilage to Regenerate

Mariam Malik ‘22 Cartilage is malleable soft tissue meant to prevent excess friction from joints rubbing against one another. Located in numerous parts of the body, such as the larynx, respiratory tract, and the septum, human cartilage is the most malleable and widespread at birth, eventually being replaced by bone. For a long time, scientists believed that cartilage in joints could not be regrown; however, … Continue reading Study Reveals Ability of Human Cartilage to Regenerate

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