
The Role of Gene Expression Variation in the Development of Mammalian Drug Resistance
Simran Kaur ‘20 Designing drugs is often challenging because identical cells within a specific network will exhibit varying genetic expression (noise), resulting in drug resistance. The source of this variation is most often stochastic, accumulations of random fluctuations occurring during transcription, translation, and post-translational regulation. Gene expression noise currently poses as the greatest barrier in finding a cure for cancer and Human Immunodeficiency Virus (HIV). … Continue reading The Role of Gene Expression Variation in the Development of Mammalian Drug Resistance