Genetic factors may be involved in disease risk of early-onset autoimmune thyroid disease

Panayiota Siskos ’23 Autoimmune thyroid diseases, such as Graves’ disease and Hashimoto’s disease, are often characterized by the infiltration of T cells and B cells in the thyroid as well as the production of antibodies specific to thyroid antigens. Genes including human leukocyte antigen (HLA), cytotoxic T lymphocyte-associated factor 4 (CTLA-4), CD40, and protein tyrosine phosphatase-22 (PTPN-22) have been previously associated with susceptibility to autoimmune … Continue reading Genetic factors may be involved in disease risk of early-onset autoimmune thyroid disease

Application of Trispecific Antibodies to Anticancer Immunotherapy

Ashley Goland ’23 Immunotherapy is a form of cancer treatment that utilizes the body’s own immune system to destroy cancerous tumors and has shown promise in past animal and clinical human trials. For all of its dazzling successes to date, however, immunotherapy is not completely effective for treating the full range of cancer types and patients— yet. Scientists working in Sanofi Research and Development believe … Continue reading Application of Trispecific Antibodies to Anticancer Immunotherapy

Comfort Eating and Cortisol Reactivity

Ayesha Azeem ‘23 “Comfort-eating,” or increased food intake, is one of the most common responses to stressful situations. Cortisol is the body’s main stress hormone that regulates metabolism and the immune response to stressful situations. Cortisol reactivity under stress can predict stress-related eating behavior and how it affects the body mass index (BMI). Based on one’s cortisol reactivity to a stressor, a person may be … Continue reading Comfort Eating and Cortisol Reactivity

Dexamethasone as a Possible Treatment for Patients Diagnosed with Acute Respiratory Distress Syndrome

Simran Kaur ‘20 Acute respiratory distress syndrome (ARDS) is characterized by the build-up of fluid in the alveoli of the lungs, the main sites of gaseous exchange, causing a lack of oxygen in the body. ARDS is caused by sudden trauma to the lungs, and there currently is no pharmacological treatment for the condition. Researchers in the study sought to determine the efficacy of dexamethasone, … Continue reading Dexamethasone as a Possible Treatment for Patients Diagnosed with Acute Respiratory Distress Syndrome

Bacteriophages as Therapeutic Targets in the Alleviation of Alcoholic Liver Disease Symptoms

Simran Kaur ‘20 The acute form of alcohol-induced liver disease, alcoholic hepatitis, has a high mortality rate, and therapy is insufficiently effective. It is known to be promoted by gut microbiota. Cytolysin, a cell-destroying substance secreted by Enterococcus faecalis, is a major cause of hepatocyte apoptosis, consequent liver injury, and progression of hepatic disease. Patients diagnosed with alcohol-dependence present with significantly higher concentrations of E. … Continue reading Bacteriophages as Therapeutic Targets in the Alleviation of Alcoholic Liver Disease Symptoms

Cardiovascular Health Benefits to Dog Ownership

Aditi Kaveti ‘23 Loneliness and depression — in addition to a lack of physical activity — can increase the risks associated with health complications and premature death. Previous studies have demonstrated the links dog ownership has with increased physical activity, reduced social isolation, and lower blood pressure. A new study conducted by Professor Tove Fall at Uppsala University in Sweden suggested that dog ownership could … Continue reading Cardiovascular Health Benefits to Dog Ownership

Better sleep quality in college students leads to better performance in classes

Joyce Chen ‘23 College students are known for being sleep-deprived, sometimes sleeping for less than four hours a day or none at all. However, a lack of sleep can result in serious health consequences, such as a weakened immune system that makes people prone to illnesses. Recent research shows that sleep can improve concentration, energy, and mental and physical health in general.  To explore this … Continue reading Better sleep quality in college students leads to better performance in classes

Short-term relationships with violent men make women more prone to gender violence

Joyce Chen ‘23 Violence against women is a common occurence worldwide. In many countries, women are sexually abused or suffer from human trafficking. However, more research is needed to uncover the underlying factors that predispose women to such violence. Researchers under Lídia Puigvert utilized the ‘Free Teen Desire’ experimental project to study the link between females’ attractions to males and future gender violence as a … Continue reading Short-term relationships with violent men make women more prone to gender violence

The Role of A Recently Discovered Protein in Obesity

Ellie Teng ‘21 Progesterone receptor membrane component 2 (PGRMC2) is a signaling protein found in various parts of the body including the uterus and liver. While it is highly expressed in fat tissue, it is also found in especially high levels in brown fat and is required for thermogenesis, the conversion of food into body heat. Researchers at the Scripps Research Institute took this knowledge … Continue reading The Role of A Recently Discovered Protein in Obesity

Viruses in Koalas Can Be Models for Genome Immunity

Ellie Teng ‘21 Retroviruses such as HIV are viruses that take genes from host cells and incorporate them into their own genomes. Transposons are DNA elements that can change positions in the genome, increasing the potential for mutations and genome instability. Piwi-interacting RNAs (piRNAs) guide the immune system towards silencing the transposons during germline development. Koalas infected by the retrovirus KoRV-A virus are immunodeficient and … Continue reading Viruses in Koalas Can Be Models for Genome Immunity