Figure 1: This is an example of a patient that shows symptoms of vitiligo. TRM cells were found to permanently reside in the affected areas and can be the key to long-term anti-tumor immunity.

Immunity to Future Cancers with Resident Memory T Cells

Richard Liang 18’ Skin cancer melanomas develop from melanocytes, or pigment-containing cells, and cause discoloration in various parts of the body. Patients with melanomas are also likely to develop an autoimmune disease known as vitiligo, in which the body’s immune system attacks melanocytes. This results in a patchy loss of pigmentation. Recently, in a study…

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Integrating Synthetic Biology with Hepatogenous Diabetes Treatments

Caleb Sooknanan ‘20 Hepatogenous diabetes is a condition often characterized by the comorbid presence of type 2 diabetes with chronic liver disease. A major factor in this condition is insulin resistance (IR), an asymptomatic disease state in which impaired insulin signaling causes organ dysfunction. Current therapies that target IR are limited and generally inapplicable for…

Figure 1. The naked mole-rat’s ability to temporarily survive without oxygen can help create new treatments for stroke and heart attack patients.

From Naked Mole-Rats to Human Treatment

By Taylor Ha ’18 Naked mole-rats are pink, wrinkly, and big-toothed. Deep underground in hypoxic, or low oxygen, and high carbon dioxide conditions, these strange creatures live in colonies of up to 280 members. And, according to a recent study published on April 21, 2017, they also have the ability to metabolize fructose, just like…

Figure 1: Through Interspecies blastocyst complementation, the blood glucose levels of diabetic mice were successfully lowered with mice pancreatic cells that were transplanted from rats.

Interspecies Pancreas Transplant

Meghan Bialt-DeCelie – ’19 Currently in the United States, 76,000 patients are deprived of potentially life-saving organ transplants. The supply of donated organs relies heavily on the number of recently deceased individuals, limiting the supply’s availability. Dr. Yomoyuki Yamaguchi and his team of researchers from Stanford University and the University of Tokyo are exploring more…