Effects of Huntington’s Disease Pathology Observable in Retinal Function

Vignesh Subramanian ’24 Huntington’s disease (HD) is a genetic neurodegenerative disorder that causes progressive development of involuntary movements and decline of memory and cognitive abilities. The disease is characterized by the aggregation of abnormally long huntingtin protein (mHtt), a product of mutations in the HTT gene that cause excessive ‘CAG’ nucleotide sequence repeats within the protein’s coding DNA sequence. Such mHtt aggregation triggers cell death … Continue reading Effects of Huntington’s Disease Pathology Observable in Retinal Function

Napping appears to have significant beneficial effects on long-term memory-retention over cramming

Priyanshi Patel ’22 Currently, there is extensive research on the cognitive effects of daytime naps, but not whether naps are a practical way to assist learning. Naps can reduce the likelihood of forgetting episodic memory consisting of life events and experiences. Prior research surrounding memory improvements have led to the idea that naps may be used as a pedagogical tool.  However, there is little evidence … Continue reading Napping appears to have significant beneficial effects on long-term memory-retention over cramming

Discovering the Role of the Neuropilin Pain Pathway in Asymptomatic COVID-19 Cases

Aditi Kaveti ’23 In the United States, there have been more than 7 million documented cases of COVID-19, leading to over 200,000 deaths nationwide. This high number of cases is due to the rapid spread of the deadly disease, which is caused by a virus called SARS-CoV-2. Many researchers believe that the rapid spread can be in part attributed to a high number of asymptomatic … Continue reading Discovering the Role of the Neuropilin Pain Pathway in Asymptomatic COVID-19 Cases

Evaluating Subgroups of Patients with Spinal Epidural Abscess

Panayiota Siskos ’23 Spinal epidural abscess (pus that has built up in tissue, organs, or spaces in the body) is a rare infection that has rising incidence, as well as high morbidity and mortality due to delayed diagnosis. These abscesses are in the epidural region (located between the outermost layer of tissue and the inside surface of bone containing the spine that runs down its … Continue reading Evaluating Subgroups of Patients with Spinal Epidural Abscess

Antibody Conditioning Enables Tolerance of Glial Grafting

Vignesh Subramanian ’24 In the central nervous system (CNS) and peripheral nervous system (PNS), glia are supportive cells that form myelin sheaths, or coatings, that insulate and protect neurons. Activated glial cells are also capable of producing growth factors such as BDNF and bFGF that trigger neuroinflammation, inducing a prolonged state of pain which alerts an organism to potential nerve injury. As such, various subtypes … Continue reading Antibody Conditioning Enables Tolerance of Glial Grafting

Melittin: A Natural Peptide from Bee Venom Which Induces Apoptosis in Human Leukemia Cells

Thumyat Noe ’23 Past research has shown that honeybee’s venom has the potential to treat various diseases such as arthritis, chronic pain, cancer, and atopic dermatitis. The venom mostly consists of peptides and low molecular weight compounds such as sugars and amino acids. Melittin is one of the peptides found within honeybee’s venom and possesses the most bioactive properties among all the compounds in the … Continue reading Melittin: A Natural Peptide from Bee Venom Which Induces Apoptosis in Human Leukemia Cells

The Questionable Validity of an FDA Approval

Leeya Azemoun, Grade 10 The Food and Drug Administration, commonly shortened to FDA, requires all medical and food products to be subject to their approval before being released on the market. This is, of course, necessary to ensure the safety of the general public who consume these products. However, there has been copious controversy over whether or not FDA approval is actually trustworthy. This concern … Continue reading The Questionable Validity of an FDA Approval

Unraveling the Ethics Behind Experimental Drugs

Aman Mistry, Grade 11 As the death toll due to COVID-19 increases, the ethical jumble surrounding experimental therapies becomes prevalent. Emergency situations such as the COVID-19 pandemic reassert the ongoing controversy surrounding the use of experimental drugs (2). Experimental drugs are preliminarily approved for clinical trials and can be alternatives to treat patients in times of crisis such as the COVID-19 pandemic or when suffering … Continue reading Unraveling the Ethics Behind Experimental Drugs

Beyond the Dichotomy: A Systematic Approach to Administering Experimental Therapies

Yashita Chaudhary, Grade 12 The 2014-2016 Zaire Ebolavirus (EBOV) outbreak can be analyzed to understand how experimental therapies can be used in times of emergency, with a particular focus on virus outbreaks. The high early mortality rates of EBOV led to doctors being spread thin, and attention quickly turned to the possibility of using experimental therapies to treat patients. Tension rose between medical staff  who … Continue reading Beyond the Dichotomy: A Systematic Approach to Administering Experimental Therapies

Cryopreservation of semen without using egg yolk

Panayiota Siskos ’23 Cryopreservation of semen conserves genetic information and allows fertilization via artificial insemination. Egg yolk is an ingredient of bull semen extender, which buffers sperm from temperature and environmental stressors. However, egg yolk composition is very variable between different producers. Cholesterol is a molecule that strengthens membrane structures. Increasing cholesterol content in sperm plasma membrane increases cryotolerance, allowing sperm to survive freezing temperatures. … Continue reading Cryopreservation of semen without using egg yolk

Cryopreservation of semen without using egg yolk

Panayiota Siskos ’23 Cryopreservation of semen conserves genetic information and allows offspring to inherit the traits of genetically superior organisms via artificial insemination. Egg yolk is an ingredient of bull semen extender, a liquid diluent that acts as a buffer that protects sperm from changes in temperature and environmental conditions. However,  egg yolk is an ingredient that is hard to standardize due to variations between … Continue reading Cryopreservation of semen without using egg yolk

How Do We Recognize Dog Emotions?

Ayesha Azeem ‘23 We humans are very complex creatures. When we spend a lot of time in close association with a species, we tend to treat them as if they are humans as well, and we can decipher their emotions clearly. With the expression of emotions, we can communicate our motivations, responses and needs to others. Recognizing animals’ emotions can be beneficial, as it may … Continue reading How Do We Recognize Dog Emotions?