Shrey Thaker ‘22 The centerpiece of clinical struggle against cancer is the recurrence of the tumor following extensive chemotherapy. The most common chemotherapeutic agent dispatched to patients suffering from colon cancer is known as 5-Fluorouracil (5-FU) and its main mechanism of action includes inducing apoptosis by inflicting DNA damage and triggering the cell’s natural apoptotic pathways. While the initial effect of tumor cell death is … Continue reading Cancer Cell Debris Generated by the Longstanding Chemotherapeutic 5-Fluorouracil is Linked to Oncogenic Inflammation
By Riya Gandhi ‘22 In the current day and age, therapeutic procedures for breast cancer–such as chemotherapy, radiation therapy, and surgery–are at the forefront of the initiative to manage cancer effectively. Across the globe, there are nations where the resources for such treatments are readily available. However, what about the low to middle income nations? Unfortunately, many of these countries, which hold higher rates of … Continue reading Utilizing Heat Shock Protein 90 in Breast Cancer Imaging: A Cheaper Alternative?
By Riya Gandhi ‘22 Due to their ability to purify blood and remove wastes, the kidneys are regarded as the filtration system for the human body. As such, they are one of the most crucial organs. However, what happens one or both of your kidneys are damaged, or worse, fail completely? Such an occurrence is known as acute kidney injury (AKI) and can transpire within … Continue reading Assessing the Risk: The Susceptibility of a Cancer Patient to Acute Kidney Injury
By Riya Gandhi ‘22 The aggressive proliferation of glioblastoma cells is characteristic of glioblastoma multiforme (GBM), a fatal cancer of the brain. As much as treatments may help, patients with this cancer typically relapse. Furthermore, radiotherapy and chemotherapy unintentionally target and poison normal proliferating cells, thereby harming the wellbeing of the patients. However, under principle investigator Dr. Yufeng Shi, researchers at the Cancer Biology & … Continue reading Invasion of the Gboxins: Inhibiting the Proliferation of Glioblastoma Cells
By Allan Mai ‘20 A sure sign of the progression of cancer occurs when tumor cells from the initial site of development breaks off and enters the bloodstream, invading other healthy tissue. A recently published study conducted by Barbara Szczerba and her team from the Cancer Metastasis Lab at the University of Basel found that circulating tumor cells (CTCs) are associated with white blood cells, … Continue reading Cancer Cells Hijack Immune Cells
By Riya Gandhi ‘22 Genotoxic stress is defined as an agent that disrupts or impairs genetic information within a cell and leads to mutations. If not repaired, these mutations often develop into cancer. Within epithelial stem cells, for example, there is a pathway called the DNA damage response (DDR) that halts the cell cycle and induces DNA repair or destruction of impaired cells through apoptosis. … Continue reading Protecting You from Yourself: The Function of Interleukin-22 Against Genotoxic Stress
By Riya Gandhi ‘22 Human cells multiply at high speeds to maintain proper functioning of the human body. Even when occur and cancerous growths appear, the cell cycle does not cease; as a result, the number of malignant cells rapidly increases. One aspect in the chemistry of cell proliferation is clear: monovalent ions contribute to the cell cycle. The specifics of their role, however, are … Continue reading Potassium’s Role in Stem Cell Proliferation
By Riya Gandhi ‘22 Although recent advancements in the field of nanomedicine are elucidating potential novel therapies for cancer, researchers have uncovered one major drawback called gap growth. Under the leadership of principal investigator Fei Peng, a recent study at the National University of Singapore discovered that the introduction of nanomaterial into animal bodies may result in micro-sized gaps in the endothelial lining, which can … Continue reading Mind the Gap! Nanoparticles Increase Endothelial Leakiness
By Ellie Teng ‘21 A prominent protein in cancer research, p53, is known for its cancer fighting abilities. p53 suppresses the initiation of tumor growth by inhibiting the cancer metabolic switch from oxidative phosphorylation to glycolysis. Glycolysis is attributed to cancer metabolism and is required for tumorigenesis, or the formation of tumors. Essentially, p53 protects the genome against mutations and prevents the mutations from being … Continue reading Protein WTp53: Fights Tumors or Boosts Cancer?
By Allan Mai ‘20 BH4 is an important regulator of many bodily functions. Among its most important functions are its involvement in the production of monoamine neurotransmitters, its generation of nitric oxide, and its role in pain. However, Shane Cronin and his team recently uncovered another important function of this cofactor: proliferation of T cells, which are an integral part of the immune response. Inhibitions … Continue reading BH4’s Role in T- Cell Proliferation in Autoimmunity and Cancer