Application of Trispecific Antibodies to Anticancer Immunotherapy

Ashley Goland ’23 Immunotherapy is a form of cancer treatment that utilizes the body’s own immune system to destroy cancerous tumors and has shown promise in past animal and clinical human trials. For all of its dazzling successes to date, however, immunotherapy is not completely effective for treating the full range of cancer types and patients— yet. Scientists working in Sanofi Research and Development believe … Continue reading Application of Trispecific Antibodies to Anticancer Immunotherapy

Different Types of Anesthesia can Impact Breast Cancer Metastasis.

Priyanshi Patel ‘22 Metastasis refers to the surgical removal of solid tumors and metastasis is the main cause of cancer death. Previously, not much was known about the role anesthetics play in cancer metastasis. Complete surgical removal of solid tumors offers the possibility of a cure and is the basic treatment provided. Despite surgery, recurrent metastasis in vital organs does reoccur and is a major … Continue reading Different Types of Anesthesia can Impact Breast Cancer Metastasis.

Disturbances in Circadian Clock Linked to Increased Susceptibility of Brain Tumors

Simran Kaur ‘20 All living organisms have circadian rhythms, an approximately twenty-four cycle that ensures the appropriate timing of important physiological functions such as digestion and sleep. Glioblastoma stem cells (GSCs) that are involved in the formation of aggressive brain tumors are stimulated by altered circadian clocks. Clock genes are responsible for the oscillation of gene expression within the day and can behave as both … Continue reading Disturbances in Circadian Clock Linked to Increased Susceptibility of Brain Tumors

CRISPR-Edited Stem Cells as a Potential Therapeutic Target for Cancer in Immunocompromised Individuals

Simran Kaur ‘20 CRISPR-Cas9 technology has been used to edit the mammalian genome for decades, allowing scientists to remove, add, and change sections of DNA sequences. The human immunodeficiency virus (HIV) does not have a cure that exists, but studies have shown that allogeneic transplantation of STEM cells into diagnosed patients can eradicate the virus. CCR5 is the coreceptor for the entry of HIV into … Continue reading CRISPR-Edited Stem Cells as a Potential Therapeutic Target for Cancer in Immunocompromised Individuals

Potential for Enhanced Cancer Therapy by Allosteric Inhibition of Phosphoglycerate Mutase

Jorge Pincay ’20 Phosphoglycerate mutase 1 (PGAM1) is a gene known to promote rapid tumor growth and invasiveness in several cancers, including non-small cell lung cancer (NSCLC). PGAM1 encodes for an enzyme that catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate in the glycolytic pathway,  a compound that coordinates anabolic biosynthesis. In many forms of cancer, including NSCLC, urothelial bladder cancer, and hepatocellular carcinoma, upregulation of … Continue reading Potential for Enhanced Cancer Therapy by Allosteric Inhibition of Phosphoglycerate Mutase

Common Fungi May Drive Pancreatic Cancer

Nicole Zhao ’20 Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide and occurs more frequently in developed countries (1). What makes pancreatic cancer even more alarming is that patients seldom exhibit symptoms until an advanced stage of the disease when little can be done for them (1). Therefore, techniques in early detection and risk assessment are crucial in the prognosis of a … Continue reading Common Fungi May Drive Pancreatic Cancer

Sugary Drinks Increase Risk of Cancer

Ellie Teng ‘21 Added sugars were long known to have adverse health benefits, but sugary drinks were recently found to be linked to cancer. An increase in the consumption of sugary drinks the past decade is associated with the increase in obesity, which is a risk factor for various cancers. In France, a group of researchers assessed the connection between  the consumption of sugary drinks … Continue reading Sugary Drinks Increase Risk of Cancer

Cancer Cell Debris Generated by the Longstanding Chemotherapeutic 5-Fluorouracil is Linked to Oncogenic Inflammation

Shrey Thaker ‘22 The centerpiece of clinical struggle against cancer is the recurrence of the tumor following extensive chemotherapy. The most common chemotherapeutic agent dispatched to patients suffering from colon cancer is known as 5-Fluorouracil (5-FU) and its main mechanism of action includes inducing apoptosis by inflicting DNA damage and triggering the cell’s natural apoptotic pathways. While the initial effect of tumor cell death is … Continue reading Cancer Cell Debris Generated by the Longstanding Chemotherapeutic 5-Fluorouracil is Linked to Oncogenic Inflammation

Utilizing Heat Shock Protein 90 in Breast Cancer Imaging: A Cheaper Alternative?

By Riya Gandhi ‘22 In the current day and age, therapeutic procedures for breast cancer–such as chemotherapy, radiation therapy, and surgery–are at the forefront of the initiative to manage cancer effectively. Across the globe, there are nations where the resources for such treatments are readily available. However, what about the low to middle income nations? Unfortunately, many of these countries, which hold higher rates of … Continue reading Utilizing Heat Shock Protein 90 in Breast Cancer Imaging: A Cheaper Alternative?

Assessing the Risk: The Susceptibility of a Cancer Patient to Acute Kidney Injury

By Riya Gandhi ‘22 Due to their ability to purify blood and remove wastes, the kidneys are regarded as the filtration system for the human body. As such, they are one of the most crucial organs. However, what happens one or both of your kidneys are damaged, or worse, fail completely? Such an occurrence is known as acute kidney injury (AKI) and can transpire within … Continue reading Assessing the Risk: The Susceptibility of a Cancer Patient to Acute Kidney Injury