Racial Disparities in Recommendation of Resective Surgery Undermines Treatment of Brain Tumors

Vignesh Subramanian ’24 Brain tumors—abnormal and typically cancerous growths of uncontrollably multiplying cells—are often first treated using a surgical approach. Benign and malignant brain tumors may be addressed with excision (partial removal) or resection (complete removal) procedures once an evaluation of surgical indications has established their necessity. As such, these procedures require the physicians with whom patients consult—whether neurosurgeons, oncologists, neurologists, or other specialties—to explicitly … Continue reading Racial Disparities in Recommendation of Resective Surgery Undermines Treatment of Brain Tumors

Bupropion as a Possible Treatment for COVID-19-Related Brain Fog

Jessica George ’24 The COVID-19 pandemic has affected millions of people worldwide, and many have reported persistent symptoms even after recovery from the initial infection. One of the most common long-term symptoms reported is “brain fog,” a condition characterized by cognitive impairments such as memory loss, difficulty concentrating, and mental fatigue. A recent case series published by Dr. Samuel Reinfeld from the Stony Brook University … Continue reading Bupropion as a Possible Treatment for COVID-19-Related Brain Fog

Racial Disparities in Childhood Adversity Exposure Influence Neuroanatomical Development

Vignesh Subramanian ’24 Childhood adversity is a broad term encompassing a range of experiences and circumstances that negatively impact a child’s well-being and development. Such circumstances include trauma and exposure to violence, all forms of abuse, neglect, exploitation, and family economic hardship, with profound and stratified implications for lifelong health. Lasting effects often include the development of toxic stress responses, accumulating hormones that over-activate certain … Continue reading Racial Disparities in Childhood Adversity Exposure Influence Neuroanatomical Development

Early Taste Experiences Drive Neural Responsiveness and Plasticity in Gustatory Cortex Circuits

Vignesh Subramanian ’24 An individual’s taste preference strongly influences their food choice, impacting their diet and, in turn, their health. Taste preference is defined as an individual’s partiality towards a particular food based on their sensory perception of its taste modalities (sweet, sour, salty, bitter, etc.), flavor, texture, and a host of other factors, and is in part guided by early experiences that identify foods … Continue reading Early Taste Experiences Drive Neural Responsiveness and Plasticity in Gustatory Cortex Circuits

Inflammatory diet associated with cognitive impairment 

By: Jessica George, Class of 2024 Figure 1: dietary patterns may predict cognitive decline in older adults Cognitive decline is a major public health concern that affects millions of older adults worldwide. Age-related cognitive decline can lead to mild cognitive impairment, dementia, and other neurodegenerative diseases. While there is no cure for these conditions, early detection and intervention can improve outcomes and quality of life … Continue reading Inflammatory diet associated with cognitive impairment 

Non-planned and impulsive suicide attempts associated with low activity of frontal brain 

By: Jessica George, Class of 2024 Figure 1: Global frontal brain activity may be a biomarker for non-planned or impulsive suicide attempts Suicide is a serious public health concern and one of the leading causes of death worldwide. One of the major challenges in preventing suicide is the frequent non-planned or impulsive nature of suicidal behavior, leaving little opportunity for intervention. Therefore, it is essential … Continue reading Non-planned and impulsive suicide attempts associated with low activity of frontal brain 

EEG Analysis Reveals Association Between Parkinson’s Disease with Visual Hallucinations and Epileptic Discharges

Jessica George ’24 Psychosis in Parkinson’s Disease (PD) is characterized by visual hallucinations (VHs). These VHs have a significant impact on patient’s lives and serve as a reliable predictor for future nursing home institutionalization. Several disorders such as Charles Bonnet syndrome and temporal lobe epilepsy have similar features to those of PD VHs. In the aforementioned disorders, EEG analysis revealed epileptiform discharges, which led researchers … Continue reading EEG Analysis Reveals Association Between Parkinson’s Disease with Visual Hallucinations and Epileptic Discharges

Exercise Was Successfully Able to Restore Brain Insulin Responsiveness in Overweight and Obese Individuals Living a Sedentary Life

Jessica George ’24 When the brain is resistant to insulin, the body tends to gain weight and distribute fat unfavorably. Resistance to insulin is one of the main characteristics of disorders such as type 2 diabetes and obesity. Today, it is unknown whether it is possible to completely reverse insulin resistance in the brain. Researchers at the Institute for Diabetes Research and Metabolic Diseases of … Continue reading Exercise Was Successfully Able to Restore Brain Insulin Responsiveness in Overweight and Obese Individuals Living a Sedentary Life

Case Study Suggests Possible Link Between Hepatitis B Vaccine and Multiple Sclerosis

Jessica George ’24 Multiple sclerosis (MS) is an immune system disorder in which the myelin sheath surrounding axons degenerates, causing system-wide brain-body disruptions. The cause of MS is unknown, but several triggers have been identified. A case study of a patient who developed MS symptoms a day after being vaccinated with hepatitis B inspired researchers from the Bassett Medical center to explore whether the hepatitis … Continue reading Case Study Suggests Possible Link Between Hepatitis B Vaccine and Multiple Sclerosis

World Trade Center Responders with Cognitive Impairment Found to Have Decreased Cerebellar Cortical Thickness

Jessica George ’24 There is no doubt that the September 11th attack on the World Trade Center (WTC) left devastating effects on the community. WTC-affected individuals, including survivors, first responders, and those involved in the clean up/recovery operation were exposed to a multitude of physical and psychological stressors. Prior neuroimaging studies demonstrate that WTC responders with cognitive impairment experienced connectivity changes in the white matter … Continue reading World Trade Center Responders with Cognitive Impairment Found to Have Decreased Cerebellar Cortical Thickness

Neuronal Firing in Thalamus is Key to Restoring Post-TBI Consciousness

Vignesh Subramanian ’24 Traumatic brain injury (TBI) is a form of acquired brain disability caused by an external force exerted against the head. The causative trauma is typically severe enough to result in loss of consciousness and the conditions under which consciousness returns remain unclear. Clinical practice uses complex electroencephalography (EEG) activity to predict its return and level, predicated on the assumption that neuronal firing … Continue reading Neuronal Firing in Thalamus is Key to Restoring Post-TBI Consciousness

Selective Striatal Neuron Degeneration in HD Linked to Autophagy Impairment

Vignesh Subramanian ’24 Huntington’s disease (HD) is an inherited neurodegenerative disease that causes the progressive breakdown of neurons over time, resulting in the development of involuntary movements (chorea), psychiatric disorders, and cognitive decline. HD is caused by the dominant mutation of the HTT gene encoding huntingtin, a protein whose normal function is unknown but is linked to projection neuron death in the striatum of the … Continue reading Selective Striatal Neuron Degeneration in HD Linked to Autophagy Impairment