Figure 1: This is an image of a typical asthma inhaler. With further development of MPPs, the drugs within these inhalers will be more effective than they are currently.

Nanoparticle Drug Delivery

Richard Liang 18’ Mucoadhesive particles (MAPs) are used as the primary method of pulmonary drug delivery since it was believed that they increase drug duration within the lungs. MAPs act by sticking to the mucus layers and are used to treat a variety of illnesses including asthma, cystic fibrosis and lung cancer. However, administered MAPs…

Figure 1: This is an example of a patient that shows symptoms of vitiligo. TRM cells were found to permanently reside in the affected areas and can be the key to long-term anti-tumor immunity.

Immunity to Future Cancers with Resident Memory T Cells

Richard Liang 18’ Skin cancer melanomas develop from melanocytes, or pigment-containing cells, and cause discoloration in various parts of the body. Patients with melanomas are also likely to develop an autoimmune disease known as vitiligo, in which the body’s immune system attacks melanocytes. This results in a patchy loss of pigmentation. Recently, in a study…

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Integrating Synthetic Biology with Hepatogenous Diabetes Treatments

Caleb Sooknanan ‘20 Hepatogenous diabetes is a condition often characterized by the comorbid presence of type 2 diabetes with chronic liver disease. A major factor in this condition is insulin resistance (IR), an asymptomatic disease state in which impaired insulin signaling causes organ dysfunction. Current therapies that target IR are limited and generally inapplicable for…

Figure 1: This is an illustration depicting the difference between healthy muscle cells (shown on the right) and muscle cells affected by muscle dystrophy (shown on the left). Due to the degeneration of the muscle cells, they will appear much smaller than usual.

Correcting Muscular Dystrophy Gene Mutations

Richard Liang 18’ Duchenne muscular dystrophy (DMD) is a severe form of muscle degeneration that can become lethal if it affects heart muscle. It is known to be caused by mutations in the X-linked dystrophin-coding gene and thus, there has been ongoing research in correcting these mutations. Currently, there is no effective treatment for this…

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A Mechanical Thorax for CPR Simulation

Caleb Sooknanan ’20 For the past few decades, cardiopulmonary resuscitation (CPR) guidelines have been regulated on the basis of chest compression, medication procedures, and other criteria. However, the circulation generated via CPR varies with intensity and duration of compressions, which can be inconsistent. As studies evaluating such inconsistencies have been relegated to animal or computer…

New and Revolutionary Treatment for Bacterial Infection

By Patrick Yang ’20 Bronchiectasis occurs when the lung’s bronchial tubes are permanently damaged or inflamed, leading to chest pain, coughing up blood, and large production of mucus. These damaged lung walls also make bronchiectasis patients more prone to chronic infection and, specifically, Pseudomonas aeruginosa lung infections, which increase mortality rates. However, previous research has…