Tag: #Alzheimer’s_disease

Brain, Degenerative Disease, General Neuroscience

Prolonged Functional Hyperemia Found in Early Stage AD in mouse models

By Asher Agarwal, Class of 2027 When a region of our brain is active, blood vessels dilate to increase blood flow and meet the increased metabolic demand of the area. This is known as functional hyperemia, or neurovascular coupling, and it is critical for maintaining metabolic homeostasis in the brain. Previous research has shown that, in response to novel environments, hippocampal inhibitory interneurons are stimulated … Continue reading Prolonged Functional Hyperemia Found in Early Stage AD in mouse models

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Biology, Cellular and Molecular Science, Molecular Biology, Synthetic Biology

Promoters of Neurodegeneration in ALS

 Sean Krivitsky ‘27 Figure 1. Drosophila melanogaster was used by the Dubnau lab as a model organism to characterize TDP-43 pathology in ALS. TAR-DNA-Binding protein (TDP-43) is an alternative splicing factor that, upon abnormal phosphorylation, can become mislocalized and aggregate in cells. This has been identified as a potential mechanism for the development of impactful neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia … Continue reading Promoters of Neurodegeneration in ALS

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