Essential Role of the MEKK3-ERK5 Module in Endothelial Cell Death

Jorge Pincay ’20 Atherosclerosis is a chronic inflammatory disease characterized by the build-up of plaque in artery walls, which can lead to coronary artery disease, heart failure, and stroke. Since atherosclerosis results from endothelial cell injury and death, researchers are making greater efforts to acquire a better understanding of the cellular mechanisms that may lead to these unfavorable changes in endothelial cells. In particular, the … Continue reading Essential Role of the MEKK3-ERK5 Module in Endothelial Cell Death

South Asians Have the Highest Rates of Heart Disease

By Nicole Zhao ’20 Heart disease is the leading cause of death for both men and women worldwide. However, people of South Asian descent have a higher death rate from heart disease than any other group. Following a variety of diets, from omnivorous to vegetarian, South Asians are four times more likely to be diagnosed with heart disease even at normal body weight and tend … Continue reading South Asians Have the Highest Rates of Heart Disease

Sleep Modulates Hematopoiesis and Protects Against Atherosclerosis

By Nicole Zhao ’20 Numerous pathological conditions such as obesity, diabetes, cancer, and cardiovascular disease have been connected to insufficient or interrupted sleep. However, little is known about the specific mechanisms by which sleep maintains health. In this study, it was found that sleep regulates hematopoiesis and protects against atherosclerosis in mice. Hematopoiesis is the process of forming blood cellular components from stem cells. Research … Continue reading Sleep Modulates Hematopoiesis and Protects Against Atherosclerosis