Tag: Cancer

Cancer, Cell Cycle

From Colon Cancer Cells to Cancer Stem Cells: The Value of Reprogramming Cells

By Riya Gandhi ‘22 The location of cancer stem cells in tumors has opened the door to the development of a variety of therapeutic applications. These cells are the future of oncology, and scientists still have much to uncover regarding their various uses in medical treatment. While cancer stem cells are treasure chests of opportunity and have wide scientific application, they are difficult to obtain. … Continue reading From Colon Cancer Cells to Cancer Stem Cells: The Value of Reprogramming Cells

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Cancer, Molecular Biology

In Situ Administration of Cytokine Combinations Could Be the Future of Immunotherapy

By Riya Gandhi ‘22 Rather than look outwards for new cancer treatments, scientists are beginning to look inwards – that is, inside the human body – for advanced therapeutic treatments. Although the use of cytokines, biomolecules that direct an immune response,in cancer therapy has been attempted for decades, there is still room for much improvement. In a recent study on cytokines, researchers under the guidance … Continue reading In Situ Administration of Cytokine Combinations Could Be the Future of Immunotherapy

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2018-19

Disruption of GABPβ1L Reverses Immortality of Glioblastoma Cells

By Riya Gandhi ‘22 Researchers in the Department of Neurological Surgery at the University of California have made a progressive discovery regarding tumor cell immortality, especially in brain-related cancers such as glioblastoma, which recently claimed the life of Senator John McCain. Their work involved TERT promoter mutations, which are responsible for activating telomerase and thereby enabling cell immortality. Approximately 90 percent of human tumors reactivate … Continue reading Disruption of GABPβ1L Reverses Immortality of Glioblastoma Cells

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2018-19

The Role of Vegetables in Cancer Therapy

By Allan Mai ‘20 It’s no secret that eating vegetables improves your health in more ways than one. A recent study is adding to the repertoire of already known health benefits; benzyl isothiocynate (BITC), a compound found in cruciferous vegetables such as cabbage, broccoli, and cauliflower, is showing indications of a role in decreasing hepatic precancerous lesions in mice. Hepatocellular carcinoma (HCC) is the most … Continue reading The Role of Vegetables in Cancer Therapy

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2017-18

Consumption of Artificially Sweetened Beverages Linked to Lower Risk of Colon Cancer

Nita Wong ‘21 While the consumption of low- and no-calorie soft drinks has long been associated with a number of diseases including obesity and diabetes, such purported health risks have yet to be scientifically or clinically documented. In fact, a recent study conducted at Yale University’s Cancer Center has shown that such artificially sweetened products actually help colon cancer survivors avoid cancer recurrence and death. … Continue reading Consumption of Artificially Sweetened Beverages Linked to Lower Risk of Colon Cancer

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2017-18

Reducing Cancer Metastasis with Gene Target Therapy

Caleb Sooknanan ‘20 Cancer metastasis refers to the spread of cancer cells from an original tumor to another bodily region through a subject’s blood or lymph systems. The possibility of cancer cells entering a subject’s blood stream is mainly dependent upon the motility of cancer cells within the subject’s body. However, more research is needed to understand and detect the genes that account for cancer … Continue reading Reducing Cancer Metastasis with Gene Target Therapy

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2017-18

Cemiplimab Found to Be Viable Treatment for Cutaneous Squamous-Cell Carcinoma

By Sahil Rawal ‘19 Cutaneous squamous-cell carcinoma is one of the most common skin cancers, and approximately 8500 people died from it as recently as 2012. A majority of patients who are diagnosed with this type of cancer are cured by surgery, but a small percent of patient are not because of metastasis or the tumor being unaffected by surgery. Since some of the markers … Continue reading Cemiplimab Found to Be Viable Treatment for Cutaneous Squamous-Cell Carcinoma

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2017-18

Cellular regulation of tumorigenesis

By Matthew Lee ‘21 Scientists and students alike are often well aware that one of the immune system’s most important roles is fighting cancer. In this effort, dendritic cells are especially important; particularly important are conventional type 1 dendritic cells (cDC1). Dendritic cells are a type of immune cell. cDCs can present tumor antigens to T cells and attract T cells via the secretion of … Continue reading Cellular regulation of tumorigenesis

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2017-18

Viral Gene Therapy Protects Tissue from Radiation

Gene Yang ‘19 Lentiviruses are a group of virus that cause deadly diseases, but these same viruses can be modified into harmless versions used in gene therapy, where the virus is used to transport a desired gene into an organism. Using this technique, scientists from The Institute of Cancer Research in London modified lentiviruses to deliver two genes into the tissue cells of rats. The … Continue reading Viral Gene Therapy Protects Tissue from Radiation

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2017-18

The Microbiome’s Influence on Immunotherapy

By: Gene Yang ‘19 When it was discovered that cancer cells with the protein PD-L1 avoid detection by the immune system, clinical trials involving PD-L1-targeted drugs emerged. These drugs, part of a class known as immune checkpoint inhibitors, block the interaction between the cancer cells’ PD-L1 protein and the immune system’s T cells, which then allows the immune system to detect and attack the tumor. … Continue reading The Microbiome’s Influence on Immunotherapy

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Figure 1. Belgian researchers have made a breakthrough in cancer research by linking fructose 1,6-bisphosphate to the production of Ras molecules, which are commonly found in tumor cells.
2017-18

Researchers Clarify the Link Between Sugar and Cancer

By Meenu Johnkutty ’21 Researchers from the Laboratory of Molecular Cell Biology in Belgium have achieved a breakthrough in cancer research. Their project, which began in 2008, finally came to completion after nine long years. The scientists’ focus was the Warburg effect, a phenomenon in which cancer cells rapidly break down sugar molecules, stimulating tumor growth. This effect was named after Nobel laureate Otto Heinrich … Continue reading Researchers Clarify the Link Between Sugar and Cancer

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Figure 1. Financial burdens are crushing.
2017-18

Financial Burdens of Cancer

By: Ramanjot Singh ’19 It is well known that cancer is one of the major cause of death around the world. However, the indirect effects of cancer are overlooked by healthcare professionals. More specifically, the decrease in productivity, emotional costs, and financial burdens brought by cancer are often neglected. Recognizing this, Dr. Van Hoang from the Hanoi University of Public Health wanted to study the … Continue reading Financial Burdens of Cancer

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