The Use of Focused Ultrasound for Enhanced Delivery of Gene Therapy Across the Blood-Brain-Barrier

Jorge Pincay ‘20 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease that results in the degradation of nerve cells in the brain over time. This disease is the result of a DNA mutation — a cytosine-adenine-guanine (CAG) trinucleotide repeat expansion– that occurs in the gene that encodes for the huntingtin (Htt) protein. This repeat expansion causes a highly toxic form of the Htt protein … Continue reading The Use of Focused Ultrasound for Enhanced Delivery of Gene Therapy Across the Blood-Brain-Barrier

Reducing Cancer Metastasis with Gene Target Therapy

Caleb Sooknanan ‘20 Cancer metastasis refers to the spread of cancer cells from an original tumor to another bodily region through a subject’s blood or lymph systems. The possibility of cancer cells entering a subject’s blood stream is mainly dependent upon the motility of cancer cells within the subject’s body. However, more research is needed to understand and detect the genes that account for cancer … Continue reading Reducing Cancer Metastasis with Gene Target Therapy

Viral Gene Therapy Protects Tissue from Radiation

Gene Yang ‘19 Lentiviruses are a group of virus that cause deadly diseases, but these same viruses can be modified into harmless versions used in gene therapy, where the virus is used to transport a desired gene into an organism. Using this technique, scientists from The Institute of Cancer Research in London modified lentiviruses to deliver two genes into the tissue cells of rats. The … Continue reading Viral Gene Therapy Protects Tissue from Radiation