Selective Striatal Neuron Degeneration in HD Linked to Autophagy Impairment

Vignesh Subramanian ’24 Huntington’s disease (HD) is an inherited neurodegenerative disease that causes the progressive breakdown of neurons over time, resulting in the development of involuntary movements (chorea), psychiatric disorders, and cognitive decline. HD is caused by the dominant mutation of the HTT gene encoding huntingtin, a protein whose normal function is unknown but is linked to projection neuron death in the striatum of the … Continue reading Selective Striatal Neuron Degeneration in HD Linked to Autophagy Impairment