Vignesh Subramanian ’24 Figure 1: The substantia nigra (SN) nucleus in the midbrain. Parkinson’s disease (PD) is an age-related, neurodegenerative movement disorder that causes a progressive loss of motor control. The disease is characterized by a loss of dopaminergic (DA) neurons in the substantia nigra (SN), a midbrain nucleus that modulates movement and reward functions. The SN is one of five subcortical nuclei that make … Continue reading PD-Modeling Midbrain Dopamine Loss Diminishes Thalamocortical Signaling