Category: Embryonic Development

Biology, Cellular and Molecular Science, Embryonic Development, Molecular Biology

GlycoSwitch: Signaling Tuner O-Glucosylation 

Author: Sajia Athai, Class of 2026 Looking through URECA presentations every year, posters detailing scientific protocols and findings of undergraduate students cover the corners of the room.  Undergraduate Advisor for Biochemistry and Animal Development Professor, Dr. Bernadette Holdener, leads her team of mentees in understanding how protein O-glucosyltransferase 2 and 3 (POGLUT2/3) is integral to separation of digits during limb development in mice.  Dr. Holdener’s … Continue reading GlycoSwitch: Signaling Tuner O-Glucosylation 

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2024-25, Biology, Cellular and Molecular Science, Chemistry, Embryonic Development, Genetics, Molecular Biology

Novel Insights Into the Mechanism of DSB Repair During Meiosis Crossover Events

Author: Sean Krivitsky, Class of 2026 Figure 1. Image of cells at various stages of meiosis. Meiosis is a key process underlying sexual reproduction and is responsible for the production of gametes, sperm, and eggs, which are necessary for fertilization. One important aspect of meiosis is that it contributes to the process of genetic diversification through genetic recombination, which involves the crossing over and independent … Continue reading Novel Insights Into the Mechanism of DSB Repair During Meiosis Crossover Events

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Embryonic Development

Reductions in Complete Rat Serum Yields Promising Results in Whole Embryo Culture

Nomrota Majumder ‘21 Whole Embryo Culture (WEC) came about in the 1950s as a way to observe patterns in mammalian development, investigate birth defects, and analyze explanted organogenesis-stage rodent embryos. Since then, it has been a very treasured technique in biological research methods. Since WEC is conducted in vitro, a serum properly suited for an embryo is crucial to the process, and ever since its … Continue reading Reductions in Complete Rat Serum Yields Promising Results in Whole Embryo Culture

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Cancer, Embryonic Development

Investigating the Link Between Cancer Cells and Embryonic Cells to Treat Cancer

By Snigdha Kanadibhotla ‘21 Fundamentally rooted in a lack of cell cycle control, cancer is predicted to affect 38.4% of Americans within their lifetimes (1). While most healthy cells are regulated by three cell cycle checkpoints, cancerous cells can bypass these regulatory systems, which leads to uncontrolled division and metastasis (the spread of cancer through the body). Considered to be a unique characteristic of cancer, … Continue reading Investigating the Link Between Cancer Cells and Embryonic Cells to Treat Cancer

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Figure 1. Close interaction between embryonic trophoblast stem cells and embryonic stem cells resembles natural embryo development.
2016-17, Embryonic Development

Scientists Create First Ever Artificial Embryo

By Patrick Yang ’20   Embryo development has been a very limited and sanctioned field of research due to concern for the pregnant mother. Although safety is a priority for live subjects, research in this area could improve understanding of optimal prenatal conditions, as well as the molecular interactions between embryonic stem cells. Researchers have thus entertained the idea of an artificial embryo because it … Continue reading Scientists Create First Ever Artificial Embryo

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