New Technology Optimizes Process for T-Cell Therapy

Rachel Kogan ‘19 T-Cells are cells involved in a particular form of immunity known as the cell-mediated immune response. The cell-mediate immune response does not utilize antibodies, or proteins that bind to and flag foreign substances as dangerous, and instead signals other cells to either engulf of attack these invaders. Typically, T-cells have been used therapeutically to treat certain forms of cancers as well as … Continue reading New Technology Optimizes Process for T-Cell Therapy

The Use of CRISPR/Cas9 Gene Editing Tool in Treating Early Onset Alzheimer’s Disease

Stephanie Budhan ‘20 Early-onset Alzheimer’s disease (AD) is dominantly inherited genetic disorder that causes the development of Alzheimer’s Disease in individuals younger than 65 years old. AD is caused by a point mutation in three major genes, one of which is amyloid precursor protein (APP). APP is cleaved to generate beta amyloid which makes up the amyloid plaque found in the brains of AD patients. … Continue reading The Use of CRISPR/Cas9 Gene Editing Tool in Treating Early Onset Alzheimer’s Disease

Figure 1. 3D render of the characteristic double helix structure of DNA. Although genes can now be easily identified and sequenced, knowledge of how nucleus structure affects gene regulation remain incomplete.

An Alternative Method to Understanding Nucleus Structure and Gene Expression

Gene Yang ‘19 Rapid growth of DNA sequencing technology in recent years has led to a wealth of data and the ability to easily identify genes and regulatory regions. However, our understanding of gene expression control, especially through long distances of several kilobases or megabases, remains limited.  As a result, the 4D Nucleome Project, an ongoing research initiative funded by the National Institutes of Health … Continue reading An Alternative Method to Understanding Nucleus Structure and Gene Expression