CRISPR-Edited Stem Cells as a Potential Therapeutic Target for Cancer in Immunocompromised Individuals

Simran Kaur ‘20 CRISPR-Cas9 technology has been used to edit the mammalian genome for decades, allowing scientists to remove, add, and change sections of DNA sequences. The human immunodeficiency virus (HIV) does not have a cure that exists, but studies have shown that allogeneic transplantation of STEM cells into diagnosed patients can eradicate the virus. CCR5 is the coreceptor for the entry of HIV into … Continue reading CRISPR-Edited Stem Cells as a Potential Therapeutic Target for Cancer in Immunocompromised Individuals

HIV Successfully Removed from Animal Genomes

Ellie Teng ‘21 The human immunodeficiency virus type one (HIV-1) is responsible for infecting millions worldwide. Currently, antiretroviral therapy (ART) is being used to slow HIV progression; however, as soon as this treatment is stopped, HIV-1 is reactivated and progresses to acquired immunodeficiency syndrome (AIDS). The reactivation of HIV-1 following the cessation of ART is as a result of the virus’ ability to integrate its … Continue reading HIV Successfully Removed from Animal Genomes

What SIV can Teach us About HIV’s March Throughout the Body

By Matthew Lee ‘21 Ever since it made a global impact in the 1980s, HIV has increasingly become one of the world’s most studied diseases. However, the exact mechanisms that underlie vertical HIV-1 transmission have yet to be fully understood. A research team led by Dr. Angela M. Amedee of Louisiana State University Health Sciences Center sought to investigate the early stages of HIV pathogenesis … Continue reading What SIV can Teach us About HIV’s March Throughout the Body

A Single-Pill HIV Treatment

By Richard Liang ’18 After extensive use of their multi-drug regimens, many HIV patients begin suffering from kidney impairment and decreased bone density. These pathologies have been recently associated with the chemical tenofovir in the medication regimens. As a response to this, the FDA approved Genvoya, a pill that minimizes tenofovir’s negative side effects. This novel pill combines dosages of active ingredients from standard medications, … Continue reading A Single-Pill HIV Treatment