Viruses in Koalas Can Be Models for Genome Immunity

Ellie Teng ‘21 Retroviruses such as HIV are viruses that take genes from host cells and incorporate them into their own genomes. Transposons are DNA elements that can change positions in the genome, increasing the potential for mutations and genome instability. Piwi-interacting RNAs (piRNAs) guide the immune system towards silencing the transposons during germline development. Koalas infected by the retrovirus KoRV-A virus are immunodeficient and … Continue reading Viruses in Koalas Can Be Models for Genome Immunity

Cellular regulation of tumorigenesis

By Matthew Lee ‘21 Scientists and students alike are often well aware that one of the immune system’s most important roles is fighting cancer. In this effort, dendritic cells are especially important; particularly important are conventional type 1 dendritic cells (cDC1). Dendritic cells are a type of immune cell. cDCs can present tumor antigens to T cells and attract T cells via the secretion of … Continue reading Cellular regulation of tumorigenesis