Tag: #Interneurons

2025-26, General Neuroscience

Cholinergic Interneurons and Nicotinic Receptors are drivers of Serotonin Release in the Dorsal Striatum

By Kang Lai 2026 The dorsal striatum is a major input region of the basal ganglia and plays critical roles in goal-directed and habit learning. Neural processes within this region are largely shaped by serotonin, also known as 5-HT. Previous research has shown that monoamines and acetylcholine (ACh) can regulate the release of each other in the striatum. For example, dopamine causes excitation of striatal … Continue reading Cholinergic Interneurons and Nicotinic Receptors are drivers of Serotonin Release in the Dorsal Striatum

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Brain, Cognition, Degenerative Disease, General Neuroscience, Neurology

Hippocampal interneuron activity drives functional hyperemia leading to neurovascular disfunction and Alzheimer’s Disease

Author: Kang Lai, Class of 2026 Functional hyperemia, or the dilation of blood vessels in response to increased metabolic activity, is critical for regulating the levels of oxygen and glucose in the brain. Moreover, it facilitates the clearance of metabolic byproducts such as amyloid-β peptide (Aβ), an accumulation of which underlies Alzheimer’s disease. In Alzheimer’s Disease (AD), disruptions in vascular dynamics are significant but poorly … Continue reading Hippocampal interneuron activity drives functional hyperemia leading to neurovascular disfunction and Alzheimer’s Disease

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