Tag: microglia

2024-25, Depression, General Neuroscience, General Psychology, Health, Health and Medicine, Neuroscience

Novel Implications of the Neuroimmune System in Major Depressive Disorder

Sean Krivitsky, Class of 2026 Every year, three million people in the United States alone are diagnosed with major depressive disorder (MDD). MDD is a serious form of mental illness that impacts countless facets of people’s lives, characterized by a persistently low mood and general impairment of daily routines. Interestingly, glial cells, generally known for their roles in regulation and support of neuronal networks in … Continue reading Novel Implications of the Neuroimmune System in Major Depressive Disorder

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Neuroscience

Anti-Microglial Hyperactivity Drug Action May Block Alzheimer’s Disease Progression

Vignesh Subramanian ’24 Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory, critical thinking skills, and behavioral capabilities that typically worsens with age. As the most common form of late-stage dementia, numerous risk alleles – variants of a gene that make a particular disease’s development more likely – have been identified for AD. Prominent among these is the triggering receptor expressed … Continue reading Anti-Microglial Hyperactivity Drug Action May Block Alzheimer’s Disease Progression

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Neuroscience

Microglial Activation Promotes AD-Affiliated Plaque Formation

Vignesh Subramanian ’24 Alzheimer’s disease (AD) is a neurodegenerative disorder and form of dementia that causes progressive loss of memory, critical thinking skills, and behavioral capabilities. The disease is characterized by the extracellular aggregation of beta (β)-amyloid plaques. These buildups gradually interfere with proteostasis, the regulation of protein synthesis and degradation, and decrease levels of neurotransmitter signaling between neurons. However, the failure of microglia – … Continue reading Microglial Activation Promotes AD-Affiliated Plaque Formation

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