Loss of NG2 Glia Implicated in Emergence of Depression Symptoms

Vignesh Subramanian ’24 Glia are non-neuronal cells that host and provide a number of homeostatic ancillary functions in both the central (CNS) and peripheral (PNS) nervous systems. Though only recently discovered and characterized, glial cells vastly outnumber neurons and provide them with structural support and insular protection, driving their myelination (the process of forming coverings known as myelin sheaths that coat neurons’ signaling axons), facilitating … Continue reading Loss of NG2 Glia Implicated in Emergence of Depression Symptoms

The Effect of Coffee and Caffeine on Healthcare Workers in Iran

Yukta Kulkarni ’22 Coffee, specifically the consumption of caffeine, is prevalent across the world. When studying the effects of caffeine on psychological disorders, previous studies have led to inconclusive results. However, most of the research has been completed in Western and first-world countries. Since there are differences in culture and nutrition in varying regions, it is important to see the effects of caffeine in other … Continue reading The Effect of Coffee and Caffeine on Healthcare Workers in Iran

History of Maternal Depression May Correlate with Hippocampal Volume in their Children

Yukta Kulkarni ’22 Depression is defined as a mental disorder in which a person has consistent feelings of sadness and a severe loss of interest. Affecting all age groups, parents can be inflicted with depression or depression-like symptoms. Previous studies have found that children of parents suffering from depression have an increased risk of developing psychiatric disorders during their lifetimes. However, the process of how … Continue reading History of Maternal Depression May Correlate with Hippocampal Volume in their Children

Early Onset Depressive Disorders in Adolescent Females

Yukta Kulkarni ’22 Depression is an illness that can cause feelings of sadness and can affect the way one thinks and acts. The first onset of depression is seen in childhood and often precedes chronic depression later on in life. Interestingly, it is correlated with differences in biological sex, as females have a 30% higher chance of struggling with first onset depression compared to males. … Continue reading Early Onset Depressive Disorders in Adolescent Females

Money Matters: Investigating Neural Responses to Monetary and Social Feedback

Thumyat Noe ’23 Depression and social anxiety disorders are two of the most common psychopathologies in adults. One way to identify these disorders is by looking at event-related potentials (ERPs) which are measurable brain responses to stimuli. “Reward positivity” is an event-related potential that reflects neural positivity toward rewards and activation of a reinforcement learning system. Previous studies suggest that smaller reward positivity potentials correlate … Continue reading Money Matters: Investigating Neural Responses to Monetary and Social Feedback

Grip Strength as an Avenue of Depression Prediction

Sooraj Shah ’24 Depression is a mental state in which individuals often feel disinterested in everyday activities, preventing them from taking advantage of life’s opportunities. Interestingly, depression seems to take a physical form as well, with muscle strength and functionality being a main area of concern. Unfortunately, muscle failures often go untreated because the majority of people with depression tend to reject treatment. In a … Continue reading Grip Strength as an Avenue of Depression Prediction

The Potential Biological Role of Latent-Phase Herpesvirus on Mental Health

Alex Moir ’23 Human herpesvirus 6B (HHV-6B) is one of the most prevalent herpesviruses amongst tested populations, with estimates placing worldwide infections near 100%. HHV-6B is neurotropic, establishing a lifelong infection in the brain and entering a period of latency in which replication and spread is inhibited. The activity of HHV-6B and its effects on the brain during latent infection are poorly understood. Examination of … Continue reading The Potential Biological Role of Latent-Phase Herpesvirus on Mental Health

The Bright Side of Winter: Battling Seasonal Depression with a Positive Mindset

Ishmam Khan ’25 Seasonal Depression, clinically recognized as Seasonal Affective Disorder, is a recurrent pattern of seasonal depression or lack of exposure to sunlight during certain seasons, especially winter. Naturally, researchers have posited several hypotheses about how this disorder originated. One popular hypothesis of the origins of this condition is the “latitude hypothesis,” which states that the further a location is from the sun, the … Continue reading The Bright Side of Winter: Battling Seasonal Depression with a Positive Mindset

Depressive symptoms can lead to a false perception of ambiguity

Joyce Chen ‘23 Unlikely to experience optimism, many depressed individuals often times perceive ambiguity in a negative fashion. Their perception of reality is morphed by their emotions and they misunderstand other people’s intentions due to their subjective feelings. They have a negatively biased interpretation of the world, thereby leading to self-doubt and isolation. Thus, a depressed disposition can cause and worsen negative ambiguity processing.  A … Continue reading Depressive symptoms can lead to a false perception of ambiguity

Potentials of Ketamine in Treating Depression

Allan Mai ‘20 Major depressive disorder (MDD) is a psychiatric illness affecting people on a global scale. There are very few drugs to treat this disorder, but the ones that do exist aim to alter the levels of neurotransmitters in the body. Ketamine is one of these drugs, and researchers have recently shown that the efficacy of the drug might be doubled as a result … Continue reading Potentials of Ketamine in Treating Depression