Selective Striatal Neuron Degeneration in HD Linked to Autophagy Impairment

Vignesh Subramanian ’24 Huntington’s disease (HD) is an inherited neurodegenerative disease that causes the progressive breakdown of neurons over time, resulting in the development of involuntary movements (chorea), psychiatric disorders, and cognitive decline. HD is caused by the dominant mutation of the HTT gene encoding huntingtin, a protein whose normal function is unknown but is linked to projection neuron death in the striatum of the … Continue reading Selective Striatal Neuron Degeneration in HD Linked to Autophagy Impairment

Compartmental function and modulation of the striatum

Sabah Bari ‘24 The striatum is one of the main input areas of the basal ganglia, a neuronal circuit necessary for voluntary movement control. It is a critical component of motor control, action selection and reward systems within the brain. Almost all elements of the brain’s reward circuit are modulated during social behavior. The striatum has two main efferent pathways. There are 2 main efferent … Continue reading Compartmental function and modulation of the striatum