Tag: #Featured

Biology, Cellular and Molecular Science, Chemistry

Exploring the Therapeutic Potential of Melatonin in Endometriosis Management

Author: Kimberly Johnston ’26 Endometriosis is defined by the growth of endometrial tissue outside the uterus where it does not belong. It occurs in about 10% of women of reproductive age and leads to chronic pelvic pain and infertility. Despite the prevalence of this disease, its cause remains unknown. While there is no known cure to endometriosis, there are methods of symptom management, including hormone … Continue reading Exploring the Therapeutic Potential of Melatonin in Endometriosis Management

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Biology, Cellular and Molecular Science, Drug Discovery

Exploring Drug Repurposing for Lacunar Stroke Prevention

Author: Kimberly Johnston ’26 Drug repurposing is a strategy that aims to find new applications for drugs that have already been proven safe and effective in humans. Lacunar stroke, characterized by reduced blood flow to the deep structures of the brain, can significantly impair a person’s movement, speech, and cognitive functions. Preventative treatments typically focus on managing hypertension, diabetes, and high cholesterol as these conditions … Continue reading Exploring Drug Repurposing for Lacunar Stroke Prevention

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Biology, Cellular and Molecular Science, Molecular Biology, Synthetic Biology

Developing Antibodies to Combat Cancer

Sean Krivitsky ‘27 Figure 1. Antibodies traveling through the bloodstream. Protein tyrosine phosphorylation is a reversible process in which a phosphate group can be added or removed from tyrosine residues of various proteins by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), respectively. This type of post-translational modification is responsible for regulating many signal transduction pathways in the cell. The activity of a specific … Continue reading Developing Antibodies to Combat Cancer

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Biology, Cancer, Cellular and Molecular Science, Health and Medicine

Breast Cancer Insights and Potential Treatments

Sean Krivitsky ‘27 Figure 1. HER2 is a protein that has been strongly implicated in many human cancers, particularly breast cancer, and has been demonstrated to induce carcinogenesis through a variety of different mechanisms. This breast cancer tissue has been stained for HER2. Some of the latest research by Stephen J. Collins of the Miller lab, a part of Stony Brook University’s Department of Physiology … Continue reading Breast Cancer Insights and Potential Treatments

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Biology, Cellular and Molecular Science, Molecular Biology

How Romantic Relationships May Reduce Inflammation

Sean Krivitsky ‘27 Figure 1. C-reactive protein (CRP) is an acute phase protein, which means that its expression increases when inflammation occurs, making it a useful inflammatory marker. Social relationships have long been recognized as playing an important role in both mental and physical health, and a groundbreaking study has demonstrated that they may influence inflammation. Recent research published in January of 2023 by Tatum … Continue reading How Romantic Relationships May Reduce Inflammation

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Biology, Cellular and Molecular Science, Molecular Biology, Synthetic Biology

Urea-Resistability of Shark Myosin: Insights into Protein Stability and Potential Therapeutic Implications

Justin Lim ’26 Figure 1: White shark.jpg Urea, a common byproduct of protein metabolism, is excreted through urine in most urea-producing organisms due to its toxic properties in high concentrations. Specifically, urea’s nitrogen content can destabilize the structure of proteins by weakening their folded structure. Sharks have chemical countermeasures to halt the progression of protein denaturation through the use of trymethylamine N-Oxide (TMAO), a molecule … Continue reading Urea-Resistability of Shark Myosin: Insights into Protein Stability and Potential Therapeutic Implications

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Cancer, Health and Medicine

Exploiting Replication Fork and Checkpoint Mechanisms: ATR Signaling and Checkpoint Inhibitors Unveil New Avenues for Targeting Cancer Replication Stress

Justin Lim ’26 Figure 1: Breast cancer cells (1).jpg Cancer, a group of diseases characterized by uncontrolled and abnormal cell growth, is generally recognized by its genomic instability built up by bypassing important biological checkpoints. These checkpoints are scattered throughout a cell’s growth period to limit the amount of DNA replication errors and other deleterious mutations during cell division. Due to the evasion of growth … Continue reading Exploiting Replication Fork and Checkpoint Mechanisms: ATR Signaling and Checkpoint Inhibitors Unveil New Avenues for Targeting Cancer Replication Stress

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Biology, Cell Cycle, Cellular and Molecular Science, Molecular Biology

Understanding how the Aging of Germline Cells “Resets” in Offspring

Sean Krivitsky ‘27 Figure 1. Section of a DNA double helix People have long been fascinated by the process of aging as well as the potential to reverse or prevent it. In particular, ribosomal DNA (rDNA) has been found to potentially play a role in aging. As aging occurs, rDNA repeats in the germline are gradually lost over time, as evidenced by the lab’s work … Continue reading Understanding how the Aging of Germline Cells “Resets” in Offspring

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Biology, Cancer, Health and Medicine, Molecular Biology

Exciting New Approach to Targeting the Mitochondria to Fight Cancer

Sean Krivitsky ‘27 Figure 1. Visualization of the mitochondria Unbeknownst to many, the mitochondria plays a significant role in carcinogenesis given the importance of metabolic processes in the formation and maintenance of tumors. CPI-613, more commonly known as devimistat, is a recently developed drug that targets a key metabolic cycle that takes place in the mitochondria of cancer cells, the tricarboxylic acid (TCA) cycle. The … Continue reading Exciting New Approach to Targeting the Mitochondria to Fight Cancer

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Biology, Health and Medicine, Molecular Biology

Improved initial assessments of severe skin burns allow for more accurate assertion of whether or not surgical intervention is required for healing

Maria Sazonova ’26  Burn injuries can result in significant skin necrosis and deep tissue damage. Severe skin burn injuries are dynamic and hard to predict; therefore, initial assessment is paramount because it forms the basis for a subsequent treatment plan. A group of Stony Brook University scientists led by M. Hassan Arbab, funded by The National Institute of General Medical Sciences, created a neural network … Continue reading Improved initial assessments of severe skin burns allow for more accurate assertion of whether or not surgical intervention is required for healing

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Uncategorized

Gold nanoparticles act as catalysts for CO oxidation

Maria Sazonova ’26 Figure 1: Electron micrograph scan of hexagonal gold nanowire array Gold nanoparticles can effectively convert carbon monoxide from harmful waste products into usable fuels. Alexander Orlov and his research team, in collaboration with Brookhaven National Lab scientists and U.S. Air Force Laboratory, conducted a study to explore how gold nanoparticles (Au NPs), widely studied for their high catalytic activity, can accelerate the … Continue reading Gold nanoparticles act as catalysts for CO oxidation

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Ecology, Evolution, Natural World

Investigating the Taxonomy of KNM-ER 1500’s Fossil Remains

Julia Chivu ’23 In the 1970s, archaeologists discovered a 15-piece fossil named KNM-ER 1500 in East Turkana, Kenya. Despite previous examinations, the classification of this fossil has not been determined,  due to severe weathering and fragmentation of the bones. Given the discovery location and morphological features, it has been suggested that KNM-ER 1500 could potentially belong to Paranthropus boisei, Homo habilis, Homo rudolfensis, or Homo … Continue reading Investigating the Taxonomy of KNM-ER 1500’s Fossil Remains

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