By Daniel Walocha ‘19 Huntington’s Disease is caused by a trinucleotide repeat of the HTT gene. The wild type has a repeat ranging from 10 to 35, but beyond 39 repeats causes the disease characterized by significant impairments in the basal ganglia and neurodegeneration. The CAG repeats in the HTT gene cause the production of an abnormally long Huntington protein, which impairs the function of … Continue reading Intelligence in the HTT Gene
Gene Yang ‘19 Methicillin-resistant Staphylococcus aureus, also known as MRSA, is an antibiotic-resistant bacteria that infects approximately 90,000 people in the United States each year. This bacteria’s resistance to many common drugs, including penicillin, makes it a rising public health care threat, yet our understanding of MRSA at the genetic level is limited. In order to bridge this gap, scientists at the University of San … Continue reading Genomic Analysis of Antibiotic Resistant Bacteria
By Marcia-Ruth Ndege ’21 In human embryos, the brain begins to develop during the first trimester of pregnancy. Proper brain development is critical at its early stages and could have detrimental effects if something goes awry. Scientists and researchers have investigated and familiarized themselves with the basics of brain development. A new study has shown that an unexpected participant plays a major role in this … Continue reading Ultraconserved Elements Found to Affect Brain Development
By Meghan Bialt-DeCelie ’19 Currently, our understanding of the genes behind skin pigmentation in humans is limited, especially for those of African heritage. Researchers led by Nicholas Crawford, PhD from the University of Pennsylvania investigated the genetic variants behind a wider range of skin colors provided from diverse African populations. Melanin is the pigment that provides the wide range of skin colors seen in the … Continue reading Genetics of Skin Pigmentation
By Meghan Bialt-DeCelie ’19 With the changing environment due to Global Climate Change, sustaining renewable resources such as crops is more important than ever. The changing climate affects the frequency of droughts and high salinity in fertile lands. These issues motivated researchers to investigate methods of increasing plant resistance to these stresses. Researchers from the Texas A&M Research Center, led by Dr. Qin, were able … Continue reading Long Non-Coding RNA’s Role in Drought Resistance
By Maryna Mullerman ’20 Human viability is the survival of individuals after birth, and more research is needed to understand how associated genetic factors affect human survival and life expectancy. Dr. Hakhamanesh Mostafavi and researchers at Columbia University in New York developed a method to recognize genetic variants that influence human survival. The proposed method would provide information about human fitness in the environment and … Continue reading What Affects Human Viability?
By Meghan Bialt-DeCelie ’19 The respiratory function of the mitochondrion, the energy producing organelle found in the cell, can decline over time. This is because of how the mitochondrion enlarge and assume a more elongated shape. Typically, that mitochondrion will eventually break down and get removed processes called mitochondrial fission and mitophagy respectively. Accumulation of the ineffective mitochondria and inability to remove them are major … Continue reading Controlling Mitochondria to Stop the Clocks
By Gene Yang ’19 Congenital heart disease is the most common birth defect in the world. This broad group of genetic conditions affect the heart’s structure and function in different ways, with symptoms ranging from harmless to fatal. However, very little is known about how a human’s genetic makeup affects cardiovascular development. A recent study, which constructed a model that predicts correlations between genetics and … Continue reading New Model Predicts How Genetics Affects Heart Structure
Meghan Bialt-DeCelie – ’19 Scientists have explored the concept of data storage in DNA, one of the most fundamental biological molecules to living things. According to the Shannon information capacity, a nucleotide can ideally contain 2 bits of data. However, DNA does not currently have this capacity due to difficulties and errors associated with high GC content and areas with long runs of the same … Continue reading Data Storage on DNA
By Rideeta Raquib ’19 The brain is a complex organ that is constantly being impacted by genetic and epigenetic factors. Mental illness patients are usually heterozygous in terms of inheriting one mutant allele. The random inactivation of the X-chromosome and genomic imprinting influences brain architecture and risk of disease. Studies on neuropsychiatric disorders uncovered a spectrum of data regarding the epigenetic dynamics of such dysfunction. … Continue reading Mammalian Brain Affected by Non-Genetic and Allele-Specific Expression
by Richard Liang ’18 Alzheimer’s disease is a major neurodegenerative condition, with individuals usually developing symptoms at ages above 65. Symptoms include impaired memory, speech, and other mental functions. Alzheimer’s has shown a correlation with increasing aggregates of Amyloid-β plaques and neurofibrillary tangles (NFTs). However, it is difficult to predict whether and at what time these plaques and tangles will be expressed in an individual. … Continue reading Genetic Vulnerability in Alzheimer’s Disease
by Julia Newman (’19) The Journal of Molecular Psychiatry recently published research that suggests a factor of predictability in children’s educational achievement. Previous studies have assumed that variances among children’s school performances may be explained by one large difference in their genetic makeup, but Dr. Selzam and his team of researchers from the Institute of Psychiatry, Psychology, and Neuroscience in London found that it is … Continue reading Predicting Your Child’s Likelihood to Succeed
Young Investigators Review 