Tag: glioblastoma

2022-23, Brain, Degenerative Disease, General Neuroscience, Year

Growth of Artificial Brain Tumors Using Three Dimensional Cell Culture

Julia Chivu ’23 Three dimensional culture systems and patient derived cells successfully allow for tumoroid development. Tumoroids are structures that grow and appear morphologically similar to naturally growing tumors in a patient. Tumoroids show promise for testing new drugs and cancer treatments. For instance, glioblastoma is a form of brain cancer that is aggressive, fast growing, and deadly. In particular, the mesenchymal subtype of this … Continue reading Growth of Artificial Brain Tumors Using Three Dimensional Cell Culture

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2018-19

Disruption of GABPβ1L Reverses Immortality of Glioblastoma Cells

By Riya Gandhi ‘22 Researchers in the Department of Neurological Surgery at the University of California have made a progressive discovery regarding tumor cell immortality, especially in brain-related cancers such as glioblastoma, which recently claimed the life of Senator John McCain. Their work involved TERT promoter mutations, which are responsible for activating telomerase and thereby enabling cell immortality. Approximately 90 percent of human tumors reactivate … Continue reading Disruption of GABPβ1L Reverses Immortality of Glioblastoma Cells

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Caption: Glioblastoma cells stained for GFAP proteins.
2017-18

New Study Shows that Sinomenine Hydrochloride Inhibits Human Glioblastoma Cell Growth

By Melvin Li ’20 Glioblastomas are among the most malignant brain tumors. People diagnosed with them, typically do not have many options for treatment due to the tumors’ abilities to resist apoptosis, or cell death. The tumors tend to grow quickly and are very aggressive; due to the amount of blood supplied to the brain, tumor cells get ample nutrients and growth factors to proliferate. … Continue reading New Study Shows that Sinomenine Hydrochloride Inhibits Human Glioblastoma Cell Growth

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