Tag: inhibition

Brain

Does Ethnicity Influence Memory Recall in Social Settings?

Daphne Siozios ’23 Collaborative learning occurs when a group of individuals works together to remember shared information and events. Not much is known about how the collaborative learning process and a social setting aids memory formation, analysis, and recollection since past research in the field has mainly focused on studying individuals in isolation. Professor Suparna Rajaram at Stony Brook University works to examine the effect … Continue reading Does Ethnicity Influence Memory Recall in Social Settings?

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Neuroscience

Presynaptic Inhibition of GABAA Receptors Possible in Thalamocortical Circuits

Vignesh Subramanian ’24 A number of neurodegenerative disease processes, including those of temporal lobe epilepsy, GABA-transaminase deficiency, and traumatic brain injury, involve disruptions to the signalling pathway of gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter of the central nervous system. Conventional understanding divides the ability of GABA to block neural signaling into ‘presynaptic inhibition’ – involving suppression of glutamate release,  an excitatory counterpart neurotransmitter – … Continue reading Presynaptic Inhibition of GABAA Receptors Possible in Thalamocortical Circuits

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Cancer, Health and Medicine, Medicine and Physiology

Potential for Enhanced Cancer Therapy by Allosteric Inhibition of Phosphoglycerate Mutase

Jorge Pincay ’20 Phosphoglycerate mutase 1 (PGAM1) is a gene known to promote rapid tumor growth and invasiveness in several cancers, including non-small cell lung cancer (NSCLC). PGAM1 encodes for an enzyme that catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate in the glycolytic pathway,  a compound that coordinates anabolic biosynthesis. In many forms of cancer, including NSCLC, urothelial bladder cancer, and hepatocellular carcinoma, upregulation of … Continue reading Potential for Enhanced Cancer Therapy by Allosteric Inhibition of Phosphoglycerate Mutase

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