Human Microbiome-Sequenced Data Yields an Antibiotic Candidate

by Jalwa Afroz ’17   Dr. John Chu and a team of researchers at Rockefeller University created a new bioinformatics approach in drug discovery to circumvent the need for bacterial culture and gene expression. Bacterial physiology is limited by the inability to culture most bacteria and also from the gene clusters silenced under lab fermentation conditions. The researchers set out to functionally characterize the data … Continue reading Human Microbiome-Sequenced Data Yields an Antibiotic Candidate

A Newly Discovered Function of Cyclin A2, a Major Regulator of Cell Cycle Progression in Tumors

by Jalwa Afroz ’17   Regulation of the cell cycle is crucial to maintain appropriate cell growth, proper chromosome replication and segregation. Cyclin A2 is one of the many cell cycle regulators that activate cyclin-dependent kinases, Cdk1 and Cdk2, which form Cyclin A2-cdk complexes that activate transcription of DNA replication factors that promote progression through the cell cycle. Conditional cyclin A2 knockout mice revealed the … Continue reading A Newly Discovered Function of Cyclin A2, a Major Regulator of Cell Cycle Progression in Tumors

Individuals of African Ancestry respond more strongly to pathogen than Individuals of European Ancestry

by Jalwa Afroz ’17   The human immune system, varying amongst individuals from different populations, evolved under selective pressure from pathogenic environments. Genome-wide association studies (GWAS) have shown extreme differences in allele frequency between various human populations for infectious, autoimmune, and inflammatory diseases. Additionally, expression quantitative trait locus (eQTL) mapping studies in antigen-exposed immune cells have identified hundreds of genetic variants that also explain variation … Continue reading Individuals of African Ancestry respond more strongly to pathogen than Individuals of European Ancestry