The Role of A Recently Discovered Protein in Obesity

Ellie Teng ‘21 Progesterone receptor membrane component 2 (PGRMC2) is a signaling protein found in various parts of the body including the uterus and liver. While it is highly expressed in fat tissue, it is also found in especially high levels in brown fat and is required for thermogenesis, the conversion of food into body heat. Researchers at the Scripps Research Institute took this knowledge … Continue reading The Role of A Recently Discovered Protein in Obesity

Cancer Cell Debris Generated by the Longstanding Chemotherapeutic 5-Fluorouracil is Linked to Oncogenic Inflammation

Shrey Thaker ‘22 The centerpiece of clinical struggle against cancer is the recurrence of the tumor following extensive chemotherapy. The most common chemotherapeutic agent dispatched to patients suffering from colon cancer is known as 5-Fluorouracil (5-FU) and its main mechanism of action includes inducing apoptosis by inflicting DNA damage and triggering the cell’s natural apoptotic pathways. While the initial effect of tumor cell death is … Continue reading Cancer Cell Debris Generated by the Longstanding Chemotherapeutic 5-Fluorouracil is Linked to Oncogenic Inflammation

Images of a Replisome Offer a New Look at DNA Replication

By Cerise Carey Scientists have never been able to capture an image of the molecules behind DNA replication until now. A team of researchers from Stony Brook University, Brookhaven National Laboratory, and Rockefeller University, including Dr. Huilin Li of Stony Brook University’s Department of Biochemistry and Cell Biology, were able to produce the first real structural image of a replisome using electron microscopy techniques. A … Continue reading Images of a Replisome Offer a New Look at DNA Replication