Tag: amyloid

Brain, Cognition, Degenerative Disease, General Neuroscience, Neurology

Hippocampal interneuron activity drives functional hyperemia leading to neurovascular disfunction and Alzheimer’s Disease

Author: Kang Lai, Class of 2026 Functional hyperemia, or the dilation of blood vessels in response to increased metabolic activity, is critical for regulating the levels of oxygen and glucose in the brain. Moreover, it facilitates the clearance of metabolic byproducts such as amyloid-β peptide (Aβ), an accumulation of which underlies Alzheimer’s disease. In Alzheimer’s Disease (AD), disruptions in vascular dynamics are significant but poorly … Continue reading Hippocampal interneuron activity drives functional hyperemia leading to neurovascular disfunction and Alzheimer’s Disease

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Biology, Cellular and Molecular Science, Degenerative Disease, discovery, General Neuroscience, Health and Medicine, Neuroscience

Inhibition of Hydrolytic Enzyme May Protect Against Manifestation of AD-Linked Phenotypes

Author: Vignesh Subramanian, Class of 2024 Figure 1: Barnes maze tests were performed to assess the spatial reference memory of the knock-in AD mouse models. Alzheimer’s disease (AD) is a progressive, neurodegenerative disease characterized by significant memory loss and cognitive decline that worsen with age. While the disease’s long-established hallmarks include the aggregation of two misfolded proteins known as beta-amyloid and phosphorylated tau, recent research … Continue reading Inhibition of Hydrolytic Enzyme May Protect Against Manifestation of AD-Linked Phenotypes

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Neuroscience

Microglial Activation Promotes AD-Affiliated Plaque Formation

Vignesh Subramanian ’24 Alzheimer’s disease (AD) is a neurodegenerative disorder and form of dementia that causes progressive loss of memory, critical thinking skills, and behavioral capabilities. The disease is characterized by the extracellular aggregation of beta (β)-amyloid plaques. These buildups gradually interfere with proteostasis, the regulation of protein synthesis and degradation, and decrease levels of neurotransmitter signaling between neurons. However, the failure of microglia – … Continue reading Microglial Activation Promotes AD-Affiliated Plaque Formation

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2017-18

Treadmill Exercise Changes the Landscape of a Diseased Brain

By Matthew Lee ‘21 Alzheimer’s disease (AD) and other neurodegenerative diseases have debilitating effects on the elderly. AD is characterized by the buildup of proteins, subtype amyloid beta (Aβ), which form plaques and can contribute to Tau build up. However, there are multiple means by which to reduce the likelihood of developing AD. Several studies have confirmed the beneficial effects of exercise on mice with … Continue reading Treadmill Exercise Changes the Landscape of a Diseased Brain

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