Microglial Activation Promotes AD-Affiliated Plaque Formation

Vignesh Subramanian ’24 Alzheimer’s disease (AD) is a neurodegenerative disorder and form of dementia that causes progressive loss of memory, critical thinking skills, and behavioral capabilities. The disease is characterized by the extracellular aggregation of beta (β)-amyloid plaques. These buildups gradually interfere with proteostasis, the regulation of protein synthesis and degradation, and decrease levels of neurotransmitter signaling between neurons. However, the failure of microglia – … Continue reading Microglial Activation Promotes AD-Affiliated Plaque Formation

Treadmill Exercise Changes the Landscape of a Diseased Brain

By Matthew Lee ‘21 Alzheimer’s disease (AD) and other neurodegenerative diseases have debilitating effects on the elderly. AD is characterized by the buildup of proteins, subtype amyloid beta (Aβ), which form plaques and can contribute to Tau build up. However, there are multiple means by which to reduce the likelihood of developing AD. Several studies have confirmed the beneficial effects of exercise on mice with … Continue reading Treadmill Exercise Changes the Landscape of a Diseased Brain