Tag: Immunology

2021-22, Health and Medicine

Investigating Interleukin-17 Activity: One Step Closer to Treating Crohn’s Disease?

Sooraj Shah ’24 About 3 million Americans have been diagnosed with Crohn’s disease, a type of inflammatory bowel disease (IBD), with foreboding statistics indicating a rise in the disease’s prevalence. Crohn’s disease debilitates a patient through inflammation of the digestive tract, leading to severe pain and cramping in the abdominal area. The inflammation associated with the IBD is a response to invading pathogens by a … Continue reading Investigating Interleukin-17 Activity: One Step Closer to Treating Crohn’s Disease?

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Health and Medicine

Maternal Transfer of Allergies to Offspring

Aditi Kaveti ’23 It is estimated that anywhere from 10 to 30 percent of the world’s population is affected by allergies, with thousands more learning to manage their new condition every week. These allergies occur when the immune system, in response to a foreign substance, produces antibodies that bind to cells, which release chemicals that trigger a reaction. Many infants experience allergic responses closely linked … Continue reading Maternal Transfer of Allergies to Offspring

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Disease, Health, Health and Medicine, Medicine and Physiology

A Long-Term Solution for Individuals Living With Peanut Allergies

Aditi Kaveti ’23 Peanut allergies affect 6% to 8% of children around the world. Living with severe allergies is extremely dangerous and requires close monitoring of the ingredients in packaged foods and at restaurants. Many packaged products warn that the food was manufactured in a facility that processes peanuts or tree nuts. These trace amounts seem inconsequential, but they can lead to severe allergic reactions. … Continue reading A Long-Term Solution for Individuals Living With Peanut Allergies

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2017-18

Predicting Heart Transplant Rejection Before It Happens

Gene Yang ‘19 After a heart transplant surgery, heart tissue biopsies must be done multiple times to survey for signs of transplant rejection. Although this heart biopsy is currently the gold standard for the detection of acute rejection, this procedure is both risky and invasive. Scientists from Huazhang University of Science and Technology, China, through their research with T lymphocyte-targeted nanobubbles, suggest a potentially non-invasive … Continue reading Predicting Heart Transplant Rejection Before It Happens

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Figure 1. MicroRNAs, miR25 and miR93, allow tumor growth by silencing cGAS resulting in suppression of immune functions.
2017-18

Micro RNA Protect Tumor Cells by Suppressing the Immune System

By Meghan Bialt-DeCelie ‘19 Cancer can thrive and spread because of its ability to inactivate immune cells and prevent the production of molecules that help in tumor recognition and suppression. Cyclic GMP-AMP synthase (cGAS) is a molecule that would typically be produced in order to signal an immune response in the presence of a tumor. Under the low oxygen microenvironment of a tumor, however, there … Continue reading Micro RNA Protect Tumor Cells by Suppressing the Immune System

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