Tag: #neurodegeneration

2025-26, General Neuroscience

Brain Senescence and TFAP4 as Regulators of Parkinson’s Disease

By Kang Lai, Class of 2026 Parkinson’s Disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra, a crucial dopamine-producing region in the midbrain. Recent studies conducted by Markus Reissland and colleagues at Stony Brook University have investigated cellular senescence transcriptional regulators as potential drivers of senescence and Parkinson’s Disease progression.. Cellular senescence is defined by … Continue reading Brain Senescence and TFAP4 as Regulators of Parkinson’s Disease

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2025-26, General Neuroscience

A Real Eye-Opener: How Demyelination May Be Linked to Poor Color Vision

By Katie Au, Class of 2029 Figure 1.  Retinal fundus photographs of the right and left eyes in a patient with acute optic neuritis, a common presenting manifestation of multiple sclerosis. Acute optic neuritis (ON) is a common first symptom for a later diagnosis of multiple sclerosis (MS). It is known that high-contrast visual acuity—the ability to read black letters on a white background—tends to … Continue reading A Real Eye-Opener: How Demyelination May Be Linked to Poor Color Vision

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Biology, Cellular and Molecular Science, Molecular Biology, Synthetic Biology

Promoters of Neurodegeneration in ALS

 Sean Krivitsky ‘27 Figure 1. Drosophila melanogaster was used by the Dubnau lab as a model organism to characterize TDP-43 pathology in ALS. TAR-DNA-Binding protein (TDP-43) is an alternative splicing factor that, upon abnormal phosphorylation, can become mislocalized and aggregate in cells. This has been identified as a potential mechanism for the development of impactful neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia … Continue reading Promoters of Neurodegeneration in ALS

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Brain, Drug Discovery, General Neuroscience, Health and Medicine, Neuroscience

AD-Linked Proteins Linked to Cognitive Impairment Following 9/11 WTC Exposure

Vignesh Subramanian ’24 Figure 1: The South Pool of the 9/11 Memorial in New York, New York Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive loss of memory and cognitive thinking skills that typically worsens with age, and is the leading cause of dementia. Key hallmarks of the disease include buildups of two particular proteins – beta-amyloid peptide and phosphorylated tau – … Continue reading AD-Linked Proteins Linked to Cognitive Impairment Following 9/11 WTC Exposure

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