Essential Role of the MEKK3-ERK5 Module in Endothelial Cell Death

Jorge Pincay ’20 Atherosclerosis is a chronic inflammatory disease characterized by the build-up of plaque in artery walls, which can lead to coronary artery disease, heart failure, and stroke. Since atherosclerosis results from endothelial cell injury and death, researchers are making greater efforts to acquire a better understanding of the cellular mechanisms that may lead to these unfavorable changes in endothelial cells. In particular, the … Continue reading Essential Role of the MEKK3-ERK5 Module in Endothelial Cell Death

HIV Successfully Removed from Animal Genomes

Ellie Teng ‘21 The human immunodeficiency virus type one (HIV-1) is responsible for infecting millions worldwide. Currently, antiretroviral therapy (ART) is being used to slow HIV progression; however, as soon as this treatment is stopped, HIV-1 is reactivated and progresses to acquired immunodeficiency syndrome (AIDS). The reactivation of HIV-1 following the cessation of ART is as a result of the virus’ ability to integrate its … Continue reading HIV Successfully Removed from Animal Genomes

A Single-Pill HIV Treatment

By Richard Liang ’18 After extensive use of their multi-drug regimens, many HIV patients begin suffering from kidney impairment and decreased bone density. These pathologies have been recently associated with the chemical tenofovir in the medication regimens. As a response to this, the FDA approved Genvoya, a pill that minimizes tenofovir’s negative side effects. This novel pill combines dosages of active ingredients from standard medications, … Continue reading A Single-Pill HIV Treatment