Reprogramming Cells May Reverse the Aging Process

Sooraj Shah ’24 Aging is a natural process by which cells are progressively unable to divide as efficiently as before, causing cell death and lysis as the functions of the cell slowly begin to decline. The main contributor to this are the telomeres at the end of our chromosomes. Telomeres get shorter as cells divide because replication cannot copy the “lagging end” of the chromosome. … Continue reading Reprogramming Cells May Reverse the Aging Process

Thalamocortical Associated Brain Injuries May be Linked to Behavioral Changes

Sooraj Shah ’24 The discussion of brain injury, particularly in contact sports such as boxing or football, has grown in importance as more and more former athletes speak out on the lingering effects years after retirement. The discovery of CTE (chronic traumatic encephalopathy) in 2002 marked the beginning of increased attention and research into traumatic brain injuries (TBI). While CTE was found to spread throughout … Continue reading Thalamocortical Associated Brain Injuries May be Linked to Behavioral Changes

Newly Discovered Functions of MAIT Cells Suggests a Possible Target for Immunotherapy and Vaccine Treatments

Sooraj Shah ’24 While much focus has been given to the COVID-19 pandemic, autoimmune diseases, such as lupus, also affect seven percent of the American population. Recent research suggests a potential link between mucosal-associated invariant T (MAIT) cells and the two diseases, as both COVID-19 and autoimmune diseases trigger increased MAIT cell response. A study led by Dr. Charles Vorkas, a professor in the Department … Continue reading Newly Discovered Functions of MAIT Cells Suggests a Possible Target for Immunotherapy and Vaccine Treatments

Usage of Music Therapy on Anxiety-Presenting COVID-19 Patients

Sooraj Shah ’24 A rise in chronic respiratory and cardiac ailments has been attributed to the coronavirus pandemic. However, one overlooked consequence of COVID-19 is isolation, which increases the risk of developing stress-related disorders, such as anxiety and depression, as patients ponder whether separation is permanent. Previous research supports music as an important tool in addressing this psychological distress, as it has been shown to … Continue reading Usage of Music Therapy on Anxiety-Presenting COVID-19 Patients

Investigating Interleukin-17 Activity: One Step Closer to Treating Crohn’s Disease?

Sooraj Shah ’24 About 3 million Americans have been diagnosed with Crohn’s disease, a type of inflammatory bowel disease (IBD), with foreboding statistics indicating a rise in the disease’s prevalence. Crohn’s disease debilitates a patient through inflammation of the digestive tract, leading to severe pain and cramping in the abdominal area. The inflammation associated with the IBD is a response to invading pathogens by a … Continue reading Investigating Interleukin-17 Activity: One Step Closer to Treating Crohn’s Disease?

Labeling High-ranking ADHD Genes for Future Diagnosis and Treatment

Yukta Kulkarni ’22 Attention deficit hyperactivity disorder (ADHD) is a common disorder prevalent in both children and adults with symptoms such as inattention, hyperactivity, and impulsiveness. The identification of certain genes associated with ADHD can improve both the understanding of the neural mechanisms that transpire and the ability to accurately diagnose and treat people with ADHD. By researching and integrating data from various research publications, … Continue reading Labeling High-ranking ADHD Genes for Future Diagnosis and Treatment

Overexpression of FABP3 contributive to Aging Skeletal Muscle via ER stress

Sooraj Shah ’24 Sarcopenia is a disease which leads to the loss of muscle mass and function by skeletal muscle. According to Dr. Stephan von Haehling (2), a professor at Charité Medical School, the disease affects nearly 5-13% of adults 60-70 years of age, and rises to 11-50% of adults 80 years of age and older. While Sarcopenia is known to be caused by factors … Continue reading Overexpression of FABP3 contributive to Aging Skeletal Muscle via ER stress

The Correlation Between Urinary Growth Factor and Brain Growth in Relation to Postnatal Development

Sooraj Shah ’24 Premature births occur in nearly 1 in every 10 cases in the United States, which can lead to numerous diverse health effects in the future. Two neurotrophic proteins which are responsible for the survival of neurons, Nerve Growth Factor(NGF) and Brain Derived Neurotrophic Factor(BDNF), are crucial for the development of the peripheral and central nervous systems. NGFs and BDNFs are critical for … Continue reading The Correlation Between Urinary Growth Factor and Brain Growth in Relation to Postnatal Development

Essential Role of the MEKK3-ERK5 Module in Endothelial Cell Death

Jorge Pincay ’20 Atherosclerosis is a chronic inflammatory disease characterized by the build-up of plaque in artery walls, which can lead to coronary artery disease, heart failure, and stroke. Since atherosclerosis results from endothelial cell injury and death, researchers are making greater efforts to acquire a better understanding of the cellular mechanisms that may lead to these unfavorable changes in endothelial cells. In particular, the … Continue reading Essential Role of the MEKK3-ERK5 Module in Endothelial Cell Death

HIV Successfully Removed from Animal Genomes

Ellie Teng ‘21 The human immunodeficiency virus type one (HIV-1) is responsible for infecting millions worldwide. Currently, antiretroviral therapy (ART) is being used to slow HIV progression; however, as soon as this treatment is stopped, HIV-1 is reactivated and progresses to acquired immunodeficiency syndrome (AIDS). The reactivation of HIV-1 following the cessation of ART is as a result of the virus’ ability to integrate its … Continue reading HIV Successfully Removed from Animal Genomes

A Single-Pill HIV Treatment

By Richard Liang ’18 After extensive use of their multi-drug regimens, many HIV patients begin suffering from kidney impairment and decreased bone density. These pathologies have been recently associated with the chemical tenofovir in the medication regimens. As a response to this, the FDA approved Genvoya, a pill that minimizes tenofovir’s negative side effects. This novel pill combines dosages of active ingredients from standard medications, … Continue reading A Single-Pill HIV Treatment