MRI Brain Mapping of Glymphatic System May Inform AD Diagnostic

Vignesh Subramanian ’24 Alzheimer’s disease (AD) is a neurodegenerative disorder and form of dementia that causes progressive loss of memory, critical thinking skills, and behavioral capabilities. Among other pathophysiological mechanisms, the disease is characterized by disruptions in the glymphatic system, which is responsible for the facilitation of cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange driving macroscopic waste and solute clearance. Breakdowns in this clearance … Continue reading MRI Brain Mapping of Glymphatic System May Inform AD Diagnostic

Treadmill Exercise Changes the Landscape of a Diseased Brain

By Matthew Lee ‘21 Alzheimer’s disease (AD) and other neurodegenerative diseases have debilitating effects on the elderly. AD is characterized by the buildup of proteins, subtype amyloid beta (Aβ), which form plaques and can contribute to Tau build up. However, there are multiple means by which to reduce the likelihood of developing AD. Several studies have confirmed the beneficial effects of exercise on mice with … Continue reading Treadmill Exercise Changes the Landscape of a Diseased Brain

A Potential New Cure for Alzheimer’s

By Richard Liang ’18 Alzheimer’s disease is a chronic neurodegenerative illness that reveals itself primarily in elderly patients. The loss of synapses in the brain leads to memory loss and, more severely, the shutdown of bodily functions. The causes of Alzheimer’s are very poorly understood making early detection particularly difficult. With a lack of early detection, Alzheimer’s is usually discovered too late to be controlled. … Continue reading A Potential New Cure for Alzheimer’s

The Virtual Path to Assessing Alzheimer’s in Humans

By Meghan Bialt-DeCelie ’19 Scientists have reported that they have developed an analogous rodent test that could aid in Alzheimer research for humans. The Morris Maze Test assesses the ability of rodents with Alzheimer’s disease to reach a pedestal in a water-filled arena. During the assessment, rodents attempt to reach the pedestal in a number of trials. In the first trial, the pedestal is shown … Continue reading The Virtual Path to Assessing Alzheimer’s in Humans