Tag: Aaron Gochman

2016-17, Medicine and Physiology

Understanding Acute and Chronic Pain

by Aaron Gochman (’18) The biological mechanisms for acute and chronic pain appear to be vastly different, with the understanding for that of chronic pain proving much more elusive. However, an international team of researchers may have discovered a link between the two in a recent study. NMDA receptors (NMDAR) have a diverse role in neurological function. They modulate neurotransmission, the process of transducing signals … Continue reading Understanding Acute and Chronic Pain

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2016-17, Biology, Medicine and Physiology

Exploring A Safer Steroid Therapy

by Aaron Gochman (’18) Most pharmacological approaches in the study of congenital adrenal hyperplasia involve the administration of corticosteroids, potent drugs that quickly affect the body. Extended use of corticosteroids, however, typically yields unpleasant metabolic side effects. Despite this weakness, corticosteroids have been the mainstream treatment in attempting to suppress adrenal androgen. However, scientists from the United Kingdom have discovered a novel approach: corticosterone, a … Continue reading Exploring A Safer Steroid Therapy

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2016-17, Biology, Engineering, Medicine and Physiology

Hippo Biology: The Next Step in Tissue Regeneration

by Aaron Gochman (’18) Traditional studies of tissue regeneration and repair have focused on delivering cells and biomaterials, compounds that will presumably grow when placed in a biologically friendly environment. A new avenue for research, however, has been revealed by a Chinese group that has chosen to focus on drug-based therapeutics instead. The study detailed a discovery in which the team found a drug, XMU-MP-1, … Continue reading Hippo Biology: The Next Step in Tissue Regeneration

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2016-17, Biology

New Structure in Brain Maturation Discovered

by Aaron Gochman (’18) Structural biology is a division within biological research that aims to discover the atomic structures of molecules and understand their functions. In a recent paper, an international team of scientists discovered the crystal structure of doublecortin-C, a protein important for neurogenesis. Doublecortin-C plays a role in maintaining the structure of neurons in the brain; mutations in this protein have been known … Continue reading New Structure in Brain Maturation Discovered

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2016-17, Biology

Mustard Oil and Menthol: More Than Just Food Products

by Aaron Gochman (’18) Ligand-gated ion channels are typically associated with receptors that are activated or deactivated upon the binding of a chemical messenger known as either an agonist or antagonist, depending on whether they activate (agonists) or deactivate (antagonists). One class of ion channels, the TRP family, has been known to be activated by thermal stimuli. Thermal stimulation of TRP ion channels certainly represents … Continue reading Mustard Oil and Menthol: More Than Just Food Products

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2016-17, Health, Medicine and Physiology

A New Approach For Treating Retinal Pathologies

by Aaron Gochman (’18) Though visual signaling and processing is detected in the eye, information must still make its way to the brain. Photoreceptors in the retina function as transducers of these signals. However, damage to photoreceptor cells can cause not only blindness but also several types of retinal diseases. Designing therapies that target photoreceptor cells has proven to be challenging given the many G-protein … Continue reading A New Approach For Treating Retinal Pathologies

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2016-17, Biology

Biotechnology Breakthrough Targets Flaviviruses

by Aaron Gochman (’18) CRISPR-Cas9, the most recent breakthrough in biotechnology research, allows for specific and precise gene editing. With countless applications, scientists all over the world seek to optimize it for use in treating myriad diseases. This week, a team of American and Chinese researchers used CRISPR-Cas9 to target flaviviruses, a group that includes West Nile, Zika, and Dengue. There are no current effective … Continue reading Biotechnology Breakthrough Targets Flaviviruses

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2016-17, Biology, Neuroscience, Psychology

The Role of Social Stress in Cocaine Addiction

by Aaron Gochman (’18) This week, scientists from the University of Texas at Austin contributed a novel idea to addiction research. Focusing on glutamatergic synaptic transmission, the primary mode of excitatory signaling in the central nervous system, the group hypothesized that social stress would lead to increased vulnerability to cocaine addiction. Specifically, the ventral tegmental area (VTA) of the brain, a prime location for dopamine … Continue reading The Role of Social Stress in Cocaine Addiction

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2016-17, Biology, Engineering

A Step Toward Synthetic Cognition and Artificial Organs

by Aaron Gochman (’18) A team of researchers from Harvard, Stanford, and Sogang University in South Korea made headlines this week with a discovery that captures the future of bioengineering. Living cardiac muscle cells were taken from rats and printed onto a robot shaped like a sting ray. The cells were engineered to express proteins that activate in response to light; when activated, the cells … Continue reading A Step Toward Synthetic Cognition and Artificial Organs

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2016-17, Biology, Chemistry

Mitochondria: Selective protein degradation ensures cellular longevity

by Aaron Gochman (’18) Mitochondria are known as the “powerhouse of the cell.” They provide energy and regulate important biological processes to ensure healthy metabolism and proper cellular function. Hence when mitochondrial dysfunction occurs, the cell is at great risk. A pair of researchers from University of Gothenburg in Sweden have characterized a pathway in which harmful mitochondrial proteins can be degraded without affecting normal … Continue reading Mitochondria: Selective protein degradation ensures cellular longevity

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2016-17, Biology, Neuroscience

Complexin induces a conformational change of the SNARE complex

by Aaron Gochman (’18) Intercellular communication in the central nervous system occurs at a synapse, the gap between two neurons. The presynaptic neuron releases a chemical messenger known as a neurotransmitter, which diffuses across the synapse and relays the signal to the postsynaptic cell. The process of releasing the neurotransmitter from the presynaptic cell is quite complicated. The mechanism includes packing the neurotransmitter inside a … Continue reading Complexin induces a conformational change of the SNARE complex

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2016-17, Biology, Neuroscience

Dual Threat: DLK as a Novel Role Player in Axonal Regeneration

by Aaron Gochman (’18) Axonal regeneration is a branch of neuroscience on the cutting edge; re-growing injured neurons is a technique that, once refined, will fundamentally change the landscape of nervous system therapies. A team of researchers from University of Michigan, Washington University in St. Louis, and University of Pennsylvania have discovered a key intracellular pathway in axonal regeneration that is conserved in both Drosophila, … Continue reading Dual Threat: DLK as a Novel Role Player in Axonal Regeneration

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