Individuals of African Ancestry respond more strongly to pathogen than Individuals of European Ancestry
by Jalwa Afroz ’17 The human immune system, varying amongst individuals from different populations, evolved under selective pressure from pathogenic environments. Genome-wide association studies (GWAS) have shown extreme differences in allele frequency between various human populations for infectious, autoimmune, and inflammatory diseases. Additionally, expression quantitative trait locus (eQTL) mapping studies in antigen-exposed immune cells have identified hundreds of genetic variants that also explain variation … Continue reading Individuals of African Ancestry respond more strongly to pathogen than Individuals of European Ancestry

