Disturbances in Circadian Clock Linked to Increased Susceptibility of Brain Tumors

Simran Kaur ‘20 All living organisms have circadian rhythms, an approximately twenty-four cycle that ensures the appropriate timing of important physiological functions such as digestion and sleep. Glioblastoma stem cells (GSCs) that are involved in the formation of aggressive brain tumors are stimulated by altered circadian clocks. Clock genes are responsible for the oscillation of gene expression within the day and can behave as both … Continue reading Disturbances in Circadian Clock Linked to Increased Susceptibility of Brain Tumors

Engineered T-cells as a Target for Fibrosis in Myocardial Disease

Simran Kaur ‘20 Fibrosis, the excessive deposition of extracellular matrix by fibroblasts into cardiac tissue, is a significant process in the development of cardiac disease and subsequent cardiac failure, but there are not many clinical treatments that can effectively target it. Cardiac fibroblasts express an antigen that can be targeted by the transplantation of antigen-specific CD8+ T-cells because CD8+ T-cells are involved in the inflammatory … Continue reading Engineered T-cells as a Target for Fibrosis in Myocardial Disease

Enhanced mRNA Gene Therapy for Critical Limb Ischemia

Jorge Pincay ‘20 Critical limb ischemia (CLI) is a cardiovascular condition characterized by severely narrowed arteries resulting from the buildup of plaque. This narrowing of the arteries  significantly reduces blood flow to the hands, feet, and legs and may lead to amputation of the affected limbs. Most patients suffering from CLI need to undergo some form of a revascularization procedure in order to combat this … Continue reading Enhanced mRNA Gene Therapy for Critical Limb Ischemia

Role of Mitochondrial Gene TFAM in The Progression of Renal Disease

Simran Kaur ‘20 Kidney fibrosis, the accumulation of excess tissue, is the last pathway in end-stage renal failure. Examination of kidneys afflicted with renal disease in both animal and human models has shown a defect in the function of mitochondria. Mitochondria are responsible for the production of energy (ATP) in the cell, funding the processes of toxic waste removal from the blood and the regulation … Continue reading Role of Mitochondrial Gene TFAM in The Progression of Renal Disease

The Genetics Behind Sleep Duration

By: Meenu Johnkutty ’21 The need to sleep is one of health and medicine’s biggest paradoxes. Though we spend nearly a third of our lives asleep, little is really known about this process. According to the American Academy of Sleep Medicine, over 30 to 35% of the population suffers from insomnia, which is characterized by a difficulty in initiating or maintaining sleep throughout the night. … Continue reading The Genetics Behind Sleep Duration

Antibiotics Do Not Affect Gene Swapping In Bacteria

By Meghan Bialt-DeCelie ’19 Antibiotics are becoming increasingly ineffective as bacteria rapidly develop resistance to them. Scientists once believed that antibiotics promote conjugation, a process in which the DNA of bacteria can be swapped for more helpful genes in order to develop a resistance. In a study led by Dr. Lingchong You of Duke University, researchers were able to determine that antibiotics actually do not increase … Continue reading Antibiotics Do Not Affect Gene Swapping In Bacteria